CV Flashcards Preview

Family Planning > CV > Flashcards

Flashcards in CV Deck (13)
Loading flashcards...
1
Q

diuretic thiazide- HCTZ, chlorthalidone

A

moa: low vol sodium depletion that leads to PVR reduction. BP= HR x SV x (v)PVR. doc when no compelling indications. Gout- absolute contraind. doesn’t work as well in renal impairment.

2
Q

beta adrenergic antagonist (BB)- (-olol)

A

moa: block adrenergic __ receptor sites, blunt catecholamine response; non-cardioselective. BP= HR(v) x SV (v) x PVR. better in young pop. contraind: heart block & poorly controlled airway dz. masks hypoglycemia sx’s. w/ dc, taper dose over 10-14 d period. only drug that affects CO and not PVR.

3
Q

alpha-beta adrenergic antagonists

A

carvedilol, labetalol. BP= HR(v) x SV(v) x PVR(v)

4
Q

ACEI= lisinopril, enalapril

A

moa: attenuate AgII (a potent vasoconstrictor that also stim adrenal catecholamine release) effect by minimizing its production (__) or blocking its action (ARB). BP= HR x SV x PVR(v). adjust dose in renal insuff. do NOT use in renal artery stenosis. mod hyperkalemia risk. most common se: cough. most dangerous se: angioedema.

5
Q

CCB= dihydropyridine: amlodipine, felodipine. nonDHP: diltiazem, verapamil.

A

moa: causes vasodilation. BP= HR x SV x PVR(v). avoid use in heart failure, renal, or hepatic impairment.

6
Q

Aldosterone antagonist= spironolactone, eplerenone

A

moa: block effects of aldosterone therefore better regulating Na+ & water homeostasis & maintenance of intravascular vol. BP= HR x SV x PVR(v). hyperkalemia risk. gynecomastia use w/ prolonged use. caution in renal impairment.

7
Q

alpha adrenergic antagonist= terazosin, doxazosin

A

moa: causes vasodilation. BP= HR x SV x PVR(v). not as solo or 1st agent- higher rate stroke, heart failure (ALLHAT). helpful in prostatism.

8
Q

centrally-acting agents= clonidine, methyldopa

A

moa: works at brain BP control center. BP= HR x SV x PVR(v). sedation risk. abrupt w/drawal of (cl) can lead to rebound htn.

9
Q

HMG CoA reductase inhibitor= statins

A

(v)LDL 18-55%. check hepatic enzymes prior to initiation to est baseline. no further routine hepatic monitoring warranted during use. t2dm risk slight inc’d. caution w/ concomitant use of grapefruit juice. check CK at initiation to est baseline. ongoing eval in absence of sx’s not warranted. AE: rhabdomyolysis & myositis.

10
Q

bile acid sequestrants= cholestyramine, colestipol, colesevelam

A

(v)LDL 15-30%. ^TG if >/=400 mg/dl. nonsystemic w/ no hepatic monitoring required. AE: GI distress.

11
Q

selective cholesterol absorption inhibitor= ezetimibe (zetia)

A

(v)LDL= 15-20%. min effect on TG. usually in combo w/ statin. few AE’s. when combined w/ simvastatin= Vytorin.

12
Q

Niacin= niapsan

A

^HDL 15-35%. (v)TG 20-50%. AE: flushing (potentially minimized by taking asa 1h prior to dose). contraind: active liver dz, severe gout, peptic ulcer.

13
Q

fibrin acid derivatives (fibrates)= gemfibrozil, fenofibrate, fenofibric acid

A

^HDL 10-20%, (v)TG 20-50%. can cause ^ in LDL-C w/ very high TG. AE: dyspepsia, gallstones, myopathy incl’ing rhabdomyolysis if taken w/ statin. v(TG) to (v) pancreatic risk not CV risk.