CV- Cholesterol

Question 1

Cholesterol Path

Answer 1

Path: need enough to make cells. Too much makes plaques. Plaques make atherosclerosis.
Pt: HDL is the good cholesterol
LDL is the bad cholesterol
Non-HDL cholesterol is what matters
Dx: Lipid Panel
Tx: Diet + exercise is always first; Adherence
F/u: Statins…..others

Question 2

Who gets a Statin?

Answer 2

1) Vascular Disease (CVA, PVD, CAD)
2) LDL greater or equal to 190
3) LDL 70-189
+ Age 40-75
+ Diabetes
4) LDL 70-189
+ Age 40-75
+ Calculated (risk factors)

Question 3

Intensity of Statins - High

Answer 3

Atorva 40,80

Rosuva 20,40

Question 4

Intensity of Statins - Moderate

Answer 4

Atorva 10,20
Rosuva 5,10
Simva 20,40
Prava 40,80
Lova 40

Question 5

Intensity of Statins - Low

Answer 5

Simva 5,10
Prava 10,20
Lova 20

Question 6

Statin Side effects

Answer 6

Check at Baseline: Lipids, A1c, CK, LFTs
check routine: Lipids q1y; A1c (DM = q3mo)

Symptoms: Muscle soreness (CK); Hepatitis (LFTs)

Question 7

Statin

Answer 7

Good effect: lower LDL, lower TG

Bad effect: Myositis, raise LFT

Question 8

Fibrates

Answer 8

Good effect: lower total cholesterol, raise HDL

Bad effect: Myositis, raise LFT

Question 9

Ezetimibe

Answer 9

Good effect: lower LDL

Bad effect: DIARRHEA

Question 10

Bile-Acid Resins

Answer 10

Good effect: lower LDL

Bad effect: Diarrhea

Question 11

Niacins

Answer 11

Good effect: raise HDL, lower LDL

Bad effect: Flushing, ASA