CVS

Question 1

Give the rule when prescribing drugs for hypertension?

Answer 1

First line if they are under 55 or not black give ACE INHIBITORS (LISINOPRIL and RAMIPRIL)
If over 55 then use calcium channel blockers

Question 2

Explain how LISINOPRIL and RAMIPRIL work, give any side effects of these drugs.

Answer 2

So these drugs are ace inhibitors, they prevent the production of angiotensin 2 and its affects…

.cough
.Angio oedema
. Renal failure
. Hyperkalaemia

Question 3

What are losasartan and candesartan?

Answer 3

They are angiotensin receptor blockers, and prevent the blocking of angiotensin 2 by binding to AT1 receptors.

Renal failure, hyperkalaemia

Question 4

Explain the MOA and side effects of the different calcium channels..

Answer 4

Benzodiazepines = diltiazem 
Dizziness 
Flushing 
Nausea 
Headache 
Palpitations 

Dihydropyridines 
AMLODIPINE 
Oedema 
SNS activation- tachycardia and palpitations 
Constipation 
Diarrhoea 
GI discomfort 

Phenylalkamines 
VERAPAMIL 
Nausea 
Vomiting 
Dizziness 
Confusion 
Coma