CYP 2D6 Review

Question 1

Fluoxetine

CYP 2D6 Inducer, Substrate or Inhibitor?

Answer 1

POTENT INHIBITOR

substrate

Question 2

Risperidone

CYP 2D6 Inducer, Substrate or Inhibitor?

Answer 2

major substrate

Question 3

Dexamethasone

CYP 2D6 Inducer, Substrate or Inhibitor?

Answer 3

inducer

Question 4

name the significant psychotropic medication inducers of CYP 2D6

Answer 4

there are NONE!

Question 5

Fluvoxamine

CYP 2D6 Inducer, Substrate or Inhibitor?

Answer 5

major substrate

Question 6

Buproprion

CYP 2D6 Inducer, Substrate or Inhibitor?

Answer 6

POTENT INHIBITOR

Question 7

methadone

CYP 2D6 Inducer, Substrate or Inhibitor?

Answer 7

inhibitor

Question 8

TCAs

CYP 2D6 Inducer, Substrate or Inhibitor?

Answer 8

substrate

Question 9

Venlafaxine

CYP 2D6 Inducer, Substrate or Inhibitor?

Answer 9

major substrate

inhibitor

Question 10

Duloxetine

CYP 2D6 Inducer, Substrate or Inhibitor?

Answer 10

substrate

major inhibitor

Question 11

Paroxetine

CYP 2D6 Inducer, Substrate or Inhibitor?

Answer 11

POTENT INHIBITOR

major substrate

Question 12

Aripiprazole

CYP 2D6 Inducer, Substrate or Inhibitor?

Answer 12

major substrate

Question 13

Sertraline

CYP 2D6 Inducer, Substrate or Inhibitor?

Answer 13

inhibitor

substrate

Question 14

Codeine

CYP 2D6 Inducer, Substrate or Inhibitor?

Answer 14

substrate

Question 15

Tamoxifen

CYP 2D6 Inducer, Substrate or Inhibitor?

Answer 15

substrate

Question 16

Tramadol

CYP 2D6 Inducer, Substrate or Inhibitor?

Answer 16

substrate

Question 17

citalopram

CYP 2D6 Inducer, Substrate or Inhibitor?

Answer 17

inhibitor

Question 18

escitalopram

CYP 2D6 Inducer, Substrate or Inhibitor?

Answer 18

inhibitor

Question 19

Ritonavir

CYP 2D6 Inducer, Substrate or Inhibitor?

Answer 19

inhibitor

Question 20

Asenapine

CYP 2D6 Inducer, Substrate or Inhibitor?

Answer 20

inhibitor

Question 21

Haloperidol

CYP 2D6 Inducer, Substrate or Inhibitor?

Answer 21

inhibitor

Question 22

beta blockers

CYP 2D6 Inducer, Substrate or Inhibitor?

Answer 22

substrate

Question 23

clozapine

CYP 2D6 Inducer, Substrate or Inhibitor?

Answer 23

substrate

Question 24

olanzapine

CYP 2D6 Inducer, Substrate or Inhibitor?

Answer 24

substrate

Question 25

vortioxetine CYP 2D6 Inducer, Substrate or Inhibitor?

Answer 25

substrate

Question 26

atomoxetine CYP 2D6 Inducer, Substrate or Inhibitor?

Answer 26

substrate

Question 27

What is the concern about prescribing risperidone and fluoxetine together

Answer 27

fluoxetine = inhibitor at 2D6 and risperidone = major substrate at 2D6 Rx of fluoxetine with risperidone INCREASES levels of risperidone

Question 28

which antidepressants should be considered carefully in someone on abilify

Answer 28

fluoxetine paroxetine buproprion --> all are potent inhibitor at 2D6 and abilify is a major substrate of 2D6--> could increase abilify levels **can DECREASE DOSE OF ABILIFY if you start one of these antidepressants and start to get side effects of abilify**

Question 29

list the 2D6 inhibitors

Answer 29

Fluoxetine +++ Paroxetine +++ Buproprion +++ Duloxetine ++ Sertraline + Methadone Ritonavir Citalopram Escitalopram Asenapine Haloperidol Venlafaxine Clomipramine

Question 30

list the CYP 2D6 substrates

Answer 30

Fluoxetine Fluvoxamine Paroxetine Risperidone Aripiprazole Venlafaxine TCAs Clozapine Olanzapine Haloperidol Citalopram Escitalopram Sertraline Duloxetine Vortioxetine Atomoxetine Codeine Tamoxifen Tramadol Beta blockers

Question 31

List the 2D6 inducers

Answer 31

Rifampin Dexamethasone