Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

8. Psychopharmacology > CYP General Review > Flashcards

CYP General Review Flashcards

(69 cards)

Start Studying
1
Q

fluvoxamine INHIBITS which CYP enzymes

A

1A2+++

2C19+++

3A4+++

2C9

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Valproic Acid INHIBITS which CYP enzymes

A

2C9 +

UGT

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

NSAIDs INHIBITS which CYP enzymes

A

UGT

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Fluoxetine INHIBITS which CYP enzymes

A

2D6+++

1A2+

2C9++

2C19+

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Paroxetine INHIBITS which CYP enzymes

A

1A2

2D6 +++

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Buproprion INHIBITS which CYP enzymes

A

2D6+++

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Sertraline INHIBITS which CYP enzymes

A

1A2+

2D6+

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Citalopram INHIBITS which CYP enzymes

A

2D6 +

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Escitalopram INHIBITS which CYP enzymes

A

2D6+

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

haldol INHIBITS which CYP enzymes

A

2D6+

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Fluconazole INHIBITS which CYP enzymes

A

2C9 +++

3A4+++

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Amiodarone INHIBITS which CYP enzymes

A

2C9 ++

2D67 +

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Caffeine INHIBITS which CYP enzymes

A

1A2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Grapefruit juice INHIBITS which CYP enzymes

A

3A4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

OCP INHIBITS which CYP enzymes

A

1A2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Clarithromycin, Erythromycin INHIBITS which CYP enzymes

A

3A4+++

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Tobacco INDUCES which CYP enzymes

A

1A2

3A4+ (NICOTINE)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Carbamazepine INDUCES which CYP enzymes

A

3A4+++

UGT++

1A2

2C9

2C19

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

phenytoin INDUCES which CYP enzymes

A

3A4+++

UGT++

1A2

2C19

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Valproic Acid INDUCES which CYP enzymes

A

2C19

(+inhibits UGT and 2C9)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

St. Johns Wort INDUCES which CYP enzymes

A

3A4++

1A2

2C19

2C9

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Lamotrigine INDUCES which CYP enzymes

A

UGT

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Topiramate INDUCES which CYP enzymes

A

3A4+

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Morphine INDUCES which CYP enzymes

A

3A4+

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Rifampin INDUCES which CYP enzymes
3A4+++ 2C9 2C19 1A2 UGT +
26
GLucocorticoids INDUCES which CYP enzymes
3A4
27
Nefazodone INHIBTIS which CYP enzymes
3A4+++
28
Caffeine is a SUBSTRATE of which CYP enzymes
1A2
29
Theophylline is a SUBSTRATE of which CYP enzymes
1A2
30
Tamoxifen is a SUBSTRATE of which CYP enzymes
2D6 3A4
31
Warfarin is a SUBSTRATE of which CYP enzymes
1A2 2C19 2C9
32
NSAIDs is a SUBSTRATE of which CYP enzymes
UGT 2C9
33
what is the CYP interaction we most associate with smoking and clozapine
via 1A2, smoking causes clozapine levels to go down
34
OCP is a SUBSTRATE of which CYP enzymes
3A4 2C9
35
what is the major psychotropic inhibitor of 3A4
fluvoxamine
36
TCAs is a SUBSTRATE of which CYP enzymes
1A2 2D6
37
Clozapine is a SUBSTRATE of which CYP enzymes
1A2+++ 2D6 3A4 2C19 UGT
38
olanzapine is a SUBSTRATE of which CYP enzymes
1A2++ 2D6
39
Risperidone is a SUBSTRATE of which CYP enzymes
1A2 2D6++ 3A4++ UGT
40
which CYP enzyme is responsible for the relationship between risperidone/ability and fluoxetine
2D6
41
which CYP enzyme is responsible for the relationship between risperidone/ability and fluvoxamine
3A4
42
Abilify is a SUBSTRATE of which CYP enzymes
2D6++ 3A4++ UGT
43
Duloxetin is a SUBSTRATE of which CYP enzymes
1A2++ 2D6
44
Mirtazapine is a SUBSTRATE of which CYP enzymes
1A2++ 3A4++
45
non LOT benzos is a SUBSTRATE of which CYP enzymes
3A4 2C19
46
LOT benzos is a SUBSTRATE of which CYP enzymes
UGT++
47
lamotrigine is a SUBSTRATE of which CYP enzymes
UGT
48
fluvoxamine is a SUBSTRATE of which CYP enzymes
1A2 2D6
49
sertraline is a SUBSTRATE of which CYP enzymes
2D6 3A4++ 2C19 2C9 2B6
50
buproprion is a SUBSTRATE of which CYP enzymes
2B6
51
buprenorphine is a SUBSTRATE of which CYP enzymes
3A4
52
methadone is a SUBSTRATE of which CYP enzymes
3A4
53
codeine is a SUBSTRATE of which CYP enzymes
2D6
54
morphine is a SUBSTRATE of which CYP enzymes
UGT
55
venlafaxine is a SUBSTRATE of which CYP enzymes
2D6++ 3A4
56
escitalopram, citalopram is a SUBSTRATE of which CYP enzymes
2D6 2C19 3A4--escitalopram only
57
paroxetine is a SUBSTRATE of which CYP enzymes
2D6
58
atomoxetine is a SUBSTRATE of which CYP enzymes
2D6
59
dexamethasone is an inducer of which cyp enzymes
2D6
60
propanolol is a SUBSTRATE of which CYP enzymes
2C19
61
inhibition of 1A2 increases serum levels of which meds/substances
olanzapine risperidone theophylline warfarin agomelatine clozapine duloxetine naproxen caffeine
62
inhibition of 2C19 increases serum levels of which meds/substances
propanolol warfarin antiepileptics
63
inhibition of 2D6 increases serum levels of which meds/substances
olanzapine risperidone vortioxetine tamoxifen--> and REDUCES effect codeine TCAs beta blockers tramadol
64
inhibition of 3A4 increases serum levels of which meds/substances
haldol levomilnacipran methadone quetiapine tamoxifen vilazodone statins
65
name an antipsychotic that has minimal or low risk of drug-drug interactions
paliperidone (does not undergo first pass metabolism)
66
list 3 antipsychotics with HIGH risk of drug-drug interactions
clozapine (3A4, 1A2 substrate) lurasidone (3A4 substrate) quetiapine (3A4 substrate)
67
list 3 antipsychotics with moderate risk for drug-drug interaction
abilify (2D6, 3A4 substrate) risperidone (3A4, 2D6 substrate) olanzapine (1A2 substrate)
68
list antidepressants with HIGH risk for drug-drug interactions
fluoxetine (2D6, 2C19 inhibitor) fluvoxamine (1A2, 2C19, 3A4 inhibitor) moclobemide (MAOi precautions) paroxetine (2D6 inhibitor) selegiline (MAOi precautions)
69
list antidepressants with low risk for drug-drug interactions
citalopram escitalopram desvenlafaxine mirtazapine venlafaxine

8. Psychopharmacology (21 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions