CYP 3A4 Review

Question 1

Fluovxamine

CYP 3A4 Inducer, Substrate or Inhibitor?

Answer 1

POTENT INHIBITOR

Question 2

Escitalopram

CYP 3A4 Inducer, Substrate or Inhibitor?

Answer 2

major substrate

Question 3

Grapefruit juice

CYP 3A4 Inducer, Substrate or Inhibitor?

Answer 3

inhibitor

Question 4

Carbamazepine

CYP 3A4 Inducer, Substrate or Inhibitor?

Answer 4

inducer

Question 5

Aripiprazole

CYP 3A4 Inducer, Substrate or Inhibitor?

Answer 5

major substrate

Question 6

Risperidone

CYP 3A4 Inducer, Substrate or Inhibitor?

Answer 6

major substrate

Question 7

Nefazodone

CYP 3A4 Inducer, Substrate or Inhibitor?

Answer 7

POTENT INHIBITOR

Question 8

St. Johns Wort

CYP 3A4 Inducer, Substrate or Inhibitor?

Answer 8

POTENT INDUCER

Question 9

Rifampin

CYP 3A4 Inducer, Substrate or Inhibitor?

Answer 9

POTENT INDUCER

Question 10

Nicotine

CYP 3A4 Inducer, Substrate or Inhibitor?

Answer 10

Inducer

Question 11

Quetiapine

CYP 3A4 Inducer, Substrate or Inhibitor?

Answer 11

major substrate

Question 12

Erythromycin

CYP 3A4 Inducer, Substrate or Inhibitor?

Answer 12

POTENT INHIBITOR

Question 13

Statins

CYP 3A4 Inducer, Substrate or Inhibitor?

Answer 13

Major substrate

Question 14

Methadone

CYP 3A4 Inducer, Substrate or Inhibitor?

Answer 14

major substrate

Question 15

Buprenorphine

CYP 3A4 Inducer, Substrate or Inhibitor?

Answer 15

major substrate

Question 16

ketoconazole

CYP 3A4 Inducer, Substrate or Inhibitor?

Answer 16

POTENT INHIBITOR

Question 17

Lurasidone

CYP 3A4 Inducer, Substrate or Inhibitor?

Answer 17

major substrate

Question 18

Sertraline

CYP 3A4 Inducer, Substrate or Inhibitor?

Answer 18

major substrate

Question 19

Clozapine

CYP 3A4 Inducer, Substrate or Inhibitor?

Answer 19

substrate

Question 20

Mirtazapine

CYP 3A4 Inducer, Substrate or Inhibitor?

Answer 20

major substrate

Question 21

Topirmate

CYP 3A4 Inducer, Substrate or Inhibitor?

Answer 21

inducer

Question 22

Ritonavir

CYP 3A4 Inducer, Substrate or Inhibitor?

Answer 22

POTENT INHIBITOR

Question 23

Morphine

CYP 3A4 Inducer, Substrate or Inhibitor?

Answer 23

inducer

Question 24

Efavirenz

CYP 3A4 Inducer, Substrate or Inhibitor?

Answer 24

inducer

Question 25

Trazodone CYP 3A4 Inducer, Substrate or Inhibitor?

Answer 25

major substrate

Question 26

OCP CYP 3A4 Inducer, Substrate or Inhibitor?

Answer 26

major substrate

Question 27

Venlafaxine CYP 3A4 Inducer, Substrate or Inhibitor?

Answer 27

substrate

Question 28

Levomilnacipran CYP 3A4 Inducer, Substrate or Inhibitor?

Answer 28

substrate

Question 29

ziprazidone CYP 3A4 Inducer, Substrate or Inhibitor?

Answer 29

substrate

Question 30

Tamoxifen CYP 3A4 Inducer, Substrate or Inhibitor?

Answer 30

substrate

Question 31

non LOT benzos CYP 3A4 Inducer, Substrate or Inhibitor?

Answer 31

substrate

Question 32

Tacrolimus CYP 3A4 Inducer, Substrate or Inhibitor?

Answer 32

substrate

Question 33

Verapamil CYP 3A4 Inducer, Substrate or Inhibitor?

Answer 33

strong inhibitor

Question 34

List the 3A4 Inhibitors

Answer 34

Fluvoxamine +++ Nefazodone +++ Erythromycin +++ Ketoconazole +++ Ritonavir +++ Grapefruit juice Verapamil Diltiazem

Question 35

List the 3A4 substrates

Answer 35

Quetiapine Abilify Risperidone Lurasidone Escitalopram Sertraline Mirtazapine Trazodone Clozapine Venlafaxine Ziprasidone Vilazodone Buspirone Haldol Pimozide non LOT benzos Methadone Buprenorphine OCP Statins Acetaminophen Tacrolimus Tamoxifen

Question 36

List the 3A4 inducers

Answer 36

Carbamazepine St. Johns Wort +++ Morphine + Nicotine + Topiramate + Phenytoin Phenobarbital Rifampin +++ Efavirenz