Cytokines Flashcards
Mitogen for all hemopoietic progenitor cells
Stromal cells of bone marrow
Stem cell factor (SCF)
Mitogen for all erythroid progenitor and precursor cells, also promoting their differentiation
Peritubular endothelial cells of the kidney; hepatocytes
Erythropoietin (EPO)
Mitogen for megakaryoblasts and their progenitor cells
Kidney and liver
Thrombopoietin (TPO)
Mitogen for all myeloid progenitor cells
Endothelial cells of bone marrow and T lymphocytes
Granulocyte-macrophage
colony-stimulating factor (GM-CSF)
Mitogen for neutrophil precursor cells
Endothelial cells of bone marrow and macrophages
Granulocyte colony-stimulating factor (G-CSF or filgrastim)
Mitogen for monocyte precursor cells
Endothelial cells of marrow and macrophages
Monocyte colony-stimulating factor (M-CSF)
Regulates activities and cytokine secretion of many leukocytes and other cells
Macrophages and T helper cells
Interleukin-1 (IL-1)
Mitogen for activated T and B cells; promotes differentiation of NK cells
Thelper cells
Interleukin-2 (IL-2)
Mitogen for all granulocyte and megakaryocyte progenitor cells
T helper cells
Interleukin-3 (IL-3)
Promotes development of basophils and mast cells and B-lymphocyte activation
T helper cells
Interleukin-4 (IL-4)
Promotes development and activation of eosinophils
T helper cells
Interleukin-5 (IL-5) or eosinophil differentiation factor (EDF)
Mitogen for many leukocytes; promotes activation of B cells and regulatory T cells
Macrophages, neutrophils, local endothelial cells
Interleukin-6 (IL-6)
Major mitogen for all lymphoid stem cells
Stromal cells of bone marrow
Interleukin-7 (IL-7)
