Cytokines and Chemokines - Jerry - Part 4 Flashcards Preview

Immuno > Cytokines and Chemokines - Jerry - Part 4 > Flashcards

Flashcards in Cytokines and Chemokines - Jerry - Part 4 Deck (10)
Loading flashcards...
1

Required to isotype switch to IgE

IL-4

2

In the presence of TGF-B,plays a role in the differentiation of Thp cells to Th17 cells

IL-6

IL-23 (in the presence of TGF & IL-6 or IL-1)

3

Down regulates production of Th2 cytokines

INF-gamma

4

Role in mobilization and activation of dendritic cells

GM-CSF (Colony stimulating factor)

5

Autoimmune disorders if Th17 cells specific for self antigen

IL-17

6

Down regulation of Th1 cytokine production

IL-4

IL-10 (through down regulating IL-12 secretion by dendritic cells and macrophages)

7

Proinflammatory cytokine that is composed of two subunits (p19 and p40). The p40 subunit is common to both IL-12 and this cytokine

IL-23

8

Enhances/Increases expression of Class I MHC on nucleated cells

INF-gamma (enhance)

IFNα and IFNβ

9

Proinflammatory – Has been shown to be elevated in several inflammatory conditions (e.g., rheumatoid arthritis and psoriasis)

IL-22

10

Suggested to be a member of the alarmin family, molecules that are released upon tissue necrosis.

IL-33