Cytokines and Chemokines - Jerry- Part 3 Flashcards Preview

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Flashcards in Cytokines and Chemokines - Jerry- Part 3 Deck (10)
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1

Hematopoiesis - Role of B and T cell differentiation. Bone marrow and thymus

IL-7

2

Activate endothelial cells leading to de novo expression of: ICAM-1, VCAM-1, and E-selectin, and enhanced expression of ICAM-2. As well, they induce endothelial cells to secrete chemokines IL-8 and MCP-1.

IL-1 and TNF (synergistic)

3

promotes pCTL to CTL differentiation

IL-2

INF-gamma

4

Shifts Th0 response to Th2 phenotype

IL-4

5

Inhibitory molecule

IL-10

6

Plays a key role in fungal infections and in extracellular bacterial infections

IL-17

7

Chemotactic for eosinophils

IL-5

Eotaxin (CCL11)

8

recruiting eosinophils to tissues

IL-5

9

Act on hypothalamus to induce fever and play a key role in lowering of blood pressure leading to shock.

IL-1 & TNF (Sytematically)

10

Enhances NK cell cytotoxicity

IL-2