Cytokines, Cell Surface Proteins Flashcards
(25 cards)
HLA associations: B27
psoriatic arthritis, ankylosing spondylitis, IBD-associated arthritis, reactive arthritis
HLA associations: B57
abacavir hypersensitivity
HLA associations: DQ2/DQ8
celiac disease
HLA associations: DR3
DM type 1, SLE, Graves disease, Hashimoto thyroiditis, Addison disease
HLA associations: DR4
rheumatoid arthritis, DM type 1, Addison disease
IL-1
causes fever, acute inflammation; activates endothelium to expression adhesion molecules; recruits WBCs; also called osteoclast-activating factor
IL-1, IL-6, and TNF-alpha can mediated fever and sepsis
IL-6
causes fever and stimulates production of acute-phase proteins
IL-1, IL-6, and TNF-alpha can mediated fever and sepsis
TNF-alpha
activates endothelium; WBC recruitment, vascular leak
causes cachexia in malignancy; maintains granulomas in TB
IL-1, IL-6, and TNF-alpha can mediated fever and sepsis
IL-8
chemotactic factor for neutrophils
IL-12
induces T cell differentiation into Th1 cells; activates NK cells
IL-2
stimulate growth of helper, cytotoxic, and regulatory T cells and NK cells
IL-3
supports growth and differentiation of bone marrow stem cells; functions like GM-CSF
INF-gamma
secreted by NK cells and T cells in response to antigen or IL-12 from macrophages
stimulates macrophages to kill phagocytosed pathogens; inhibits differentiation of Th2 cells; induces IgG isotype switching; increases MHC expression
IL-4
induces differentiation of T cells into Th2 cells; promotes growth of B cells; enhances IgE class switching
IL-5
promotes growth and differentiation of B cells; enhances class switching to IgA; stimulates growth/differentiation of eosinophils
IL-10
attenuates inflammatory response; decreases expression of MHC class II and Th1 cytokines; inhibits activated macrophages and dendritic cells
secreted by T regulatory cells
IL-13
promotes IgE production; induces alternative macrophage activation
T cell surface proteins
TCR, CD3, CD28
TCR binds antigen-MHC complex, CD3 is associated with TCR for signal transduction, CD28 binds B7 on APC
helper T cell surface proteins
CD4, CD40L, CXCR4/CCR5 (coreceptors for HIV)
cytotoxic T cell surface proteins
CD8
regulatory T cell surface proteins
CD4, CD25
B cell surface proteins
Ig (binds antigen), CD19, CD20, CD21 (receptor for EBV), CD40, MHC II, B7 (CD80/86)
NK cell surface proteins
CD16 (binds Fc of IgG), CD56
macrophage surface proteins
CD14 (receptor for PAMPs), CD40, CCR5, MHC II, B7, Fc and C3b receptors
