Cytokines / Growth Factors

Question 1

EPO - Primary Cell Source

Answer 1

 Kidney (peritubular interstitial cell)

Question 2

G-CSF - Primary Cell Source

Answer 2

 Endothelial cells
 Placenta
 Monocytes
 Macrophages

Question 3

GM-CSF - Primary Cell Source

Answer 3

 T cells
 Macrophages
 Endothelial cells
 Fibroblasts
 Mast cells

Question 4

IL-2 - Primary Cell Source

Answer 4

 CD4+ T cells
 NK cells
 B cells

Question 5

IL-3 - Primary Cell Source

Answer 5

 Activated T cells
 NK cells

Question 6

IL-6 - Primary Cell Source

Answer 6

 T cells
 Macrophages
 Fibroblasts

Question 7

IL-10 - Primary Cell Source

Answer 7

 CD4+, Th2 T cells
 CD8+ T cells
 Monocytes
 Macrophages

Question 8

IL-12 - Primary Cell Source

Answer 8

Macrophages

Question 9

IL-15 - Primary Cell Source

Answer 9

Activated CD4+ T cells

Question 10

IFN-a - Primary Cell Source

Answer 10

 Dendritic cells
 NK cells
 T cells
 B cells
 Macrophages
 Fibroblasts
 Endothelial cells
- Osteoblast

Question 11

EPO - Primary Target Cell

Answer 11

 Bone marrow erythroid progenitors (BFU-E and CFU-E)

Question 12

G-CSF - Primary Target Cell

Answer 12

 Neutrophil precursors
 Fibroblasts
 Leukemic myeloblasts

Question 13

GM-CSF - Primary Target Cell

Answer 13

 Bone marrow progenitor cells
 Dendritic cells
 Macrophages
 NKT cells

Question 14

IL-2 - Primary Target Cell

Answer 14

 T cells
 NK cells
 B cells
 Monocytes

Question 15

IL-3 - Primary Target Cell

Answer 15

 Hematopoietic stem cells and progenitors

Question 16

IL-6 - Primary Target Cell

Answer 16

 T cells
 B cells
 Liver

Question 17

IL-10 - Primary Target Cell

Answer 17

 T cells
 Macrophages

Question 18

IL-12 - Primary Target Cell

Answer 18

 T cells

Question 19

IL-15 - Primary Target Cell

Answer 19

 CD4+ T cells
 CD8+ T cells
 NK cells

Question 20

IFN-a - Primary Target Cell

Answer 20

 Macrophages
 NK cells

Question 21

EPO - Biological Activity

Answer 21

 Simulates proliferation of erythroid progenitors and prevents apoptosis of CFU-E

Question 22

G-CSF - Biological Activity

Answer 22

 Stimulates granulocyte colonies
 Differentiation of progenitors toward neutrophil lineage
 Stimulation of neutrophil maturation

Question 23

GM-CSF - Biological Activity

Answer 23

 Promotes antigen presentation
 T cell homeostasis
 Hematopoietic cell growth factor

Question 24

IL-2 - Biological Activity

Answer 24

 Cell growth/activation of CD4+
and CD8+ T cells
 Suppress Treg responses
 Mediator of immune tolerance

Question 25

IL-3 - Biological Activity

Answer 25

 Proliferation of hematopoietic progenitors

Question 26

IL-6 - Biological Activity

Answer 26

 Co-stimulation with other cytokines  Cell growth/activation of T cells and B cells  Megakaryocyte maturation  Neural differentiation  Acute phase reactant

Question 27

IL-10 - Biological Activity

Answer 27

 Inhibits cytokine production  Inhibits macrophages

Question 28

IL-12 - Biological Activity

Answer 28

 T cell, Th1 differentiation

Question 29

IL-15 - Biological Activity

Answer 29

 CD4+/CD8+ T cell proliferation  CD8+/NK cell cytotoxicity

Question 30

IFN-a - Biological Activity

Answer 30

 Antiviral  Enhances MHC expression

Question 31

used to treat neutropenia

Answer 31

G-CSF

Question 32

panmyeloid growth factor

Answer 32

GM-CSF

Question 33

essential for lymphocyte survival and proliferation

Answer 33

IL-7

Question 34

stimulate cytotoxic T cells, eosinophil. immunoglobulin secretion

Answer 34

IL-5

Question 35

T-cell growth factor, Mast-cell stimulating factor

Answer 35

IL-9