Cytology Eval II - Ex 6 Flashcards Preview

724 Clin Path > Cytology Eval II - Ex 6 > Flashcards

Flashcards in Cytology Eval II - Ex 6 Deck (37):
1

3 Common Benign Epithelial Neoplasms

1. Papilloma 2. Adenoma 3. Basal Cell tumors

2

Papilloma

Keratinized epithelial cells

3

Adenoma

Tight clusters of vacuolated cells

4

Basal cell tumors

Tight sheets of cells with high N:C ratio

5

Sebaceous hyperplasia & sebaceous adenomas

Have the same cytologic appearance: - arranged in thick clumps - round cells with abundant, highly vacuolated, basophilic cytoplasm - small, round nucleus with dense chromatin **Sebaceous carcinomas are rare

6

Q image thumb

Sebaceous Adenoma 

 

**red lines mark the cell junctions 

7

Q image thumb

Sebaceous Adenoma 

8

9

Follicular Tumors 

**Contain basal epithelial cells 

- arranged in sheets (very distinct cell junctions; cobblestone appearance) 

- scant, lightly basophilic cytoplasm 

- small, round nucleus with dense chromatin 

 

**Common on the head and neck 

 

10

Benign Follicular tumors 

- in cats & horses: basal cell tumors 

- in dogs: trichoblastomas 

- specific classification requires histopathologic examination 

11

Malignant Follicular basal cell tumors 

- relatively common in CATS 

- rare in dogs 

- based upon the degree of malignant transformation observed 

- should be confirmed histologically 

12

Common Malignant Epithelial Neoplasms (4) 

1. Adenocarcinoma 

- 68-75% of nasal tumors in dogs 

 

2. Squamous cell carcinoma 

 

3. Transitional cell carcinoma 

 

4. Anal sac adenocarcinoma 

- neuroendorcrine appearance 

- few characteristics of malignancy 

13

Adenocarcinoma 

- sheets of cells often with acinar structures 

- cells with "signet ring" appearance 

- marked anisocytosis and anisokaryosis 

- severely anaplastic nasal tumors can have lymphoid appearance 

14

Q image thumb

Adenocarcinoma 

15

Anal Gland Tumors 

- Common in dogs --> BAD! 

- rare in cats 

- have malignant behavior

- may induce hypercalcemia 

- check sublumbar lymph nodes for metastasis 

 

16

Anal Gland Tumors - Cytologic Appearance 

- Neuroendocrine with several free round nuclei assoc'd with a background of basophilic cytoplasm 

 

- Distinct epithelial cell borders are rare 

 

- Characteristics of malignancy are rare, but tumors typically are malignant 

17

Q image thumb

Apocrine Gland Anal Sac Adenocarcinoma (AGASACA) 

 

Poor prognosis 

18

Other common epithelial Neoplasms (3) 

1. Mammary tumors 

2. Perianal gland tumors 

3. Thyroid tumors 

- neuroendocrine appearance 

19

Perianal Gland Tumors 

* Common in dogs 

* most are benign 

* located on the caudal half of the animal 

* often large and lobulated 

* responsive to androgens 

* submit histopathology to determine if they are adenomas or carcinomas 

20

Benign Mesenchymal Tumors 

* Lack characteristics of malignancy 

- lipomas

- fibromas

- neurofibromas

- myxomas

- nerve-sheath tumors 

- perivascular wall tumors 

- sarcoids (horses) 

 

* May become locally invasive and cause severe disease 

* rarely metastasize 

21

Lipomas 

Acellular samples common 

 

Adipocytes with large cytoplasmic vacuoles and very small nuclei 

22

Fibromas and Neurofibromas 

- same cytologic appearance 

- low numbers of small spindle-shaped cells 

- thin, centrally-located, oval nuclei 

- very uniform 

23

Benign Mesenchymal Tumors 

They lack characteristics of malignancy

- Fibromas 

- Neurofibromas 

- Myxomas 

- Nerve-sheath tumors 

- Perivascular wall tumors 

- Sarcoids (horses) 

 

* May become locally invasive & cause severe dz 

 

* rarely metastasize 

 

 

 

 

24

Sarcomas 

Malignant mesenchymal tumors 

 

- fibrosarcoma 

- neurofibrosarcoma 

- myxosarcoma 

- hemangiosarcoma 

- histiocytic sarcoma 

 

* Extensive local tissue invasion 

* metastasize, except histiocytic sarcoma 

25

Fibrosarcoma 

* soft-tissue sarcoma 

 

* spindle-shaped cells 

 

* marked nuclear variability 

 

* prominent nucleoli 

26

Q image thumb

Fibrosarcoma 

27

6 types of round cell tumors 

1. MCT 

2. Plasma cell tumor 

3. Histiocytoma 

4. Transmissible Venereal tumor (TVT) 

5. Lymphoma 

6. Melanoma 

28

MCT - cytolgic appearance 

- individualized round cells 

- round, centrally located nucleus 

- filled wiht metachromatic cytoplasmic granules 

- +/- eosinophils &/or reactive fibroblasts 

- occasionally, granules will not stain with Diff-Quik stain 

29

Q image thumb

Mast Cell Tumors 

30

Plasma Cell Tumor (Plasmacytoma) 

- individualized riound cells 

- abundent, basophilic cytoplasm 

- round, eccentrically placed nucleus 

- perinuclear clearing in the area of the Golgi zone 

- binucleation is common finding 

 

*usually benign 

 

31

Q image thumb

Plasma Cell Tumor 

32

HIstiocytoma 

- common in dogs 

- spontaneously regree w/in a few months of dx

 

- appearance: 

individualized round cells 

lightly basophilic cytoplasm that becomes paler toward the edges of the cell 

ovoid, eccentrically placed nucleus 

mitotic figures 

often with a basophilic proteinaceous background 

infiltrate of small lymphocytes is seen as these tumors regress

33

Q image thumb

Histiocytoma 

34

Transmissible Venereal Tumor 

- common in dogs from tropical areas 

- typically ocur around genitals & muzzle --> can spread 

- appearance: 

individualized round cells 

abundant, lightly basophilic cytoplasm 

round, centrally located nucleus 

round, clear, distinct cytoplasmic vacuoles 

 

35

Q image thumb

TVT

36

Cutaneous Lymphoma 

- multiple skin lesions may be seen 

- plaque-like lesions common 

- appearance: 

monomorphic pop of lymphocytes

lymphocytes may be small, intermed, or large 

 

*most cutaneous lymphomas are T cells 

37

Melanoma 

Appearance: 

- individualized or aggregated 

- spindle-shaped or round 

- round to variably-shaped nucleus 

- large number of BROWN-BLACK melanin granules