Muscle - Ex 3

Question 1

What 2 leakage enzymes are most often used to detect injury to mm?

Answer 1

CK and AST

Question 2

Which tissues have the highest conc of CK

Answer 2

1. Skeletal m
2. Cardiac m
3. Smooth m
4. brain

Question 3

Ck and AST

Answer 3

CK and AST both increase due to mm injury, but CK begins to fall before AST

Question 4

Inc in only CK

Answer 4

Acute m injury

Question 5

Inc in CK and AST

Answer 5

active or recent m injury

Question 6

inc in only AST

Answer 6

m injury stopped more than 2 days earlier, and CK has returned to normal due to short 1/2 life

or

inc in only AST may result from liver injury

Question 7

Which enzyme is most muscle specific?

Answer 7

CK

Question 8

Which passes the glomerulus more easily?

Answer 8

Myoglobin

• low MW and not significantly bound to protein