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Cell Bio > Cytoskeleton 1 + 2 > Flashcards

Cytoskeleton 1 + 2 Flashcards

exam 1

1
Q

size order of the filaments

A

microtubules> intermediate filaments> actin microfilaments

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2
Q

smallpox virus

A

variola

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3
Q

examples of pathogens that hijack the actin machinery of the host cell to propel themselves from one cell into another without being exposed to the immune system

A

smallpox virus, vaccinia virus and bacterium listeria

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4
Q

subunit of microtubules

A

tubulin

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5
Q

subunit of microfilaments

A

actin

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6
Q

subunit of intermediate filaments

A

lamins, keratin, desmin, neurofilaments, vimentin, GFAP

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7
Q

Acessory proteins of microtubules

A

Tau, MAPs

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8
Q

hyperstable structures of microtubules

A

axonemes (cilia and flagella) and centrioles

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9
Q

hyperstable structures of microfilaments

A

sarcomere (muscles) and microvilli

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10
Q

hyperstable structures of intermediate filaments

A

desmosome and hemi-desmosome

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11
Q

motors of microtubules

A

dynein (retrograde) and kinesin (orthograde)

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12
Q

motors of mycrofilaments

A

myosin

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13
Q

motors of intermediate filaments

A

none

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14
Q

funtion of microtubules

A

cilia/flagella functions, mitotic spindel, organelle transport

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15
Q

functions of microfilaments

A

phagocytosis, cytokinesis, cell motility, force generation (muscle), mebrane stabilization (RBC)

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16
Q

functions of intermediate filaments

A

mechanical integrity (nucleus, cell-cell, cell matrix)

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17
Q

Drugs of microtubules

A

taxol, vinca alkaloids (colchicine, vinblastine)

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18
Q

medical significance of microtubules

A

karatageners (primary Ciliary Dyskinesia, Immotile Cilia syndrome)
cancer chemotherapy dementias (Tau-opathies)

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19
Q

medical significance of microfilaments

A

listeria infection

smallpox/vaccinia

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20
Q

medical significance of intermediate filaments

A

laminopathies
blistering diseases
cancer diagnosis

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21
Q

Can you tell the size of fluorescence cells?

A

NO!

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22
Q

synapse to the cell bosy

A

retrogade

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23
Q

cell body to the synapse

A

orthograde

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24
Q

centrosomes are

A

microtubules based structures

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25
replicate during the cell cycle and become the mitotic spindle apparatus
centrosomes
26
true or false: microtubules can have different roles based on their structures
true
27
triplet microtublues are _______ than double structure
stronger
28
Cili microtubules order
cartwheel structure at the botto, a triplet mt to be a strong base, hollow mt space for cilia function, common mt formation for the rest.
29
dynein fruntion
motor for mitotic spindle and retrogade transport
30
Kartagener's
Primary Ciliary dyskinesia
31
Immotile Cilia syndrome
Kartagener's/ microtubules dysfunction
32
oocyte on drugs
taxol
33
binds to microtubules and "freezes them". They can not assemble and disassemble
Taxol
34
prevent mt from assembling
colchine, vinblastine
35
tau proteins attach to ______ and caps the end to stop them from growing
MT
36
important to regulate the mt length
Tau
37
stress fibers
actin
38
localized only in cells at the migrating front
Beta actin
39
actin seen in all cells
alpha actin
40
Actin pairs with _______ to generate force in muscle cells
Myosin
41
hyperstable actin structure
sarcomere
42
cytokinesis is an ____ based process
actin based process
43
Platelet Aggregation is
Actin-dependent
44
Phagocytosis is an
actin-mediated process
45
rapid actin assembly in phagocytosis causes
invagination
46
microvilli
specialized actin structure
47
smaller than cilia
microvilli
48
microvilli functions
increases absorption, contains a terminal web for stability
49
bacteria that uses the dark side of polymerization
listeria
50
great model system for studying membrane-cytoskeleton interactions
erythocytosis
51
hereditary spherocytosis
membrane-cytoskeleton interaction
52
spleenomegaly
hereditary spherocytosis
53
stereocilia
actin based
54
not cell type specific, always present in cells
lamins
55
muscle cells (smooth, striated, cardiac)
desmin
56
neurons
neurofilamin
57
epithelial cells
keratin
58
glial cells (astrocytes)
glial fibrillary acidic protein (GFAP)
59
many mesenchymal cells, including endothelial cells and fibroblasts
vimentin
60
desmosomes are a type
of junction between cells
61
anchors skin cells to the basal lamina
hemidesmosome
62
epidermolysis bullosa
blistering disease

Cell Bio (10 decks)

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