Cytotoxic Chemotherapy Flashcards Preview

Haematology > Cytotoxic Chemotherapy > Flashcards

Flashcards in Cytotoxic Chemotherapy Deck (18)
Loading flashcards...
1
Q

Two types of chemo?

A

Cell cycle specific

Non-cell cycle specific

2
Q

Are cell cycle specific chemos tumour specific or not?

A

Yes, tumour specific

3
Q

What are the types of cell cycle specific chemotherapies?

A

Antimetabolites

Mitotic spindle inhibitors

4
Q

In cell cycle specific agents, is dose or duration more important?

A

Duration

5
Q

What is methotrexate?

A

An Antimetabolite

6
Q

What is the action of methotrexate?

A

Inhibits dihydrofolate reductase

7
Q

What is hydroxyurea and what is its action?

A

Antimetabolite
Also know as hydroxycarbamide
Impaired deoxynucleotide synthesis

8
Q

Are non cell cycle specific agents tumour specific?

A

No. Also damage normal stem cells

9
Q

Is dose or duration more important in non cell specific agents?

A

Dose

10
Q

Examples of non cell specific agents?

A

Alkylating agents

Cytotoxic antibodies

11
Q

What is chlorambucil?

A

An Alkylating agent

12
Q

Alkylating agent mode of action??

A

Bind covalently to bases of DNA .

Pride DNA mutation by free radical production

13
Q

What are anthracyclines?

A

Cytotoxic antibiotics

14
Q

Examples of anthracyclines?

A

Daunorubicin

Doxorubicin

15
Q

Action of cytotoxic antibodies?

A

Impairs RNA transcription

Strand breaks in DNA

16
Q

Immediate side effects of non-cell cycle specific agents?

A

Bone marrow suppression
Gut mucosal damage
Hair loss

17
Q

Long term side effect of anthracyclines?

A

Cardiomyopathy

18
Q

Long term side effects of Alkylating agents ?

A

Infertility

Secondary malignancy