Day 3 Flashcards
(41 cards)
What do motor neurons connect with?
They connect with skeletal muscles
What do motor neurons tell the skeletal muscle to do?
They tell them to contract
Both neurons and muscles are what?
Both are excitable cells
Both neurons and muscles respond to stimuli by changing their what?
By changing their resting membrane potential
What is an action potential?
It is a large change in a membrane potential that spreads rapidly over long distances with a cell
What do motor neurons use as a neurotransmitter?
Acetylcholine (ACh)
What does acetylcholine do for motor neurons?
It tells the skeletal muscle to contract
Chemically gated ion channels are opened by what
They are open by chemical messengers
What do chemically gated ion channels create?
They create small local changes in membrane potential
What do voltage gated ion channels do?
They open or close and response to changes in the membrane potential
The axon of each motor, neuron branches as it enters the what?
The muscle
What does the axon form as it branches?
It forms a neuromuscular junction with a single muscle fiber
The axon terminal and muscle fiber are separated by what?
The synaptic cleft
What does the synaptic cleft separate?
The axon terminal and muscle fiber
Synaptic vesicles with the axon terminal contains what
Acetylcholine
The muscle fibers sarcolemma Has junctional folds with what?
ACh receptors
Name the sequence of events leading to contraction
A motor neuron fires, an action potential down its axonThe motor neurons axon terminal releases ACh into the synaptic cleftACH binds receptors on the junctional folds of the sarcolemmaACH binding causes a local deep polarization called an end plate potentialThe local depolarization, triggers an action potential in the Adjacent sarcolemmaThe action potential in sarcolemma travels down T tubulesSarcoplasmic reticulum releases CA +2CA +2 binds to trombone which chefs trip said to uncover the finding sites on actinMyosin heads, bind actin, and contraction occurs via Crossbridge cycling
What is excitation contraction coupling?
It is the sequence of events by which an action potential along the circle Lima leads to the sliding of myo filaments
The action potential propagates along where
The Sarcolemma and down the T tubules
The transition of the AP along the T tubules causes what?
It causes voltage sensitive to be proteins to change shape, opening CA +2 release channels in the SR
In excitation contraction coupling, calcium ions flow into what?
Into the cytosol
In excitation contraction coupling, Calcium ions bind what?
Troponin
In excitation contraction coupling Calcium ions, remove what?
Removes the blocking action Of tropomyosin
In excitation contraction coupling, Myosin binding sites on the thin filaments are exposed and ready for what?
Myosin binding