Day 5

Question 1

Explain the change in WBC cell size as it matures

Answer 1

Size decreases as it matures

Question 2

Explain the changes in WBC cell nucleus as it matures.

Answer 2

Nucleus is larger and nucleoli disappears

Question 3

If you’re unsure about the maturity classification of a cell, what should you do?

Answer 3

classify to the most mature stage

Question 4

What is leukopoiesis?

Answer 4

The production of WBCs

Question 5

What are two groups of WBCs ?

Answer 5

Granulocytic and Agranulocytic

Question 6

Where do granulocytes develop?

Answer 6

Bone marrow

Question 7

Describe the two different types of granules found in granulocytes

Answer 7

Primary- coarse and dark blue staining

Secondary- replace primary granules as cells develop

Question 8

What are the three cell types in granulocytic series?

Answer 8

Eosinophils, Basophils and Neutrophils

Question 9

Describe the granules of an eosinophil

Answer 9

They stain bright red-orange; equal in size and found in the cytoplasm

Question 10

Describe the granules of a basophil

Answer 10

They stain black to purple; unequal in size, found in cytoplasm and may obscure the nucleus

Question 11

In order from immature to mature , list the maturation sequence of granulocytes

Answer 11

Myeloblast
Promyelocyte
Myelocyte
Metamyelocyte
Band Neutrophil
Segmented Neutrophil

Question 12

What granulocytic maturation sequence is described: the nucleus is round or slightly flattened on one side with NO nucleoli

Answer 12

Myelocyte

Question 13

When is a myeloblast classified as a promyelocyte?

Answer 13

When is develops distinct granules

Question 14

What is the last stage in the granulocytic series that is capable of cell division?

Answer 14

Myelocyte

Question 15

Which stage of the granulocytic series is the dawn of neutrophilia seen?

Answer 15

Myelocyte

Question 16

Which stage of the granulocytic series can we first distinguish between neutrophils, eosinophils and basophils?

Answer 16

Myelocyte

Question 17

What granulocytic maturation sequence is described: the nucleus is indented or kidney bean shaped?

Answer 17

Metamyelocyte

Question 18

Describe what the metamyelocyte granules look like for each cell type?

Answer 18

Neutrophils- granules are pinker and more numerous
Eosinophils- granules are brighter orange-red and more numerous
Basophils- granules are dark purple and more numerous

Question 19

What must be true about the nucleus of a cell in order to classify as a Band Neutrophil?

Answer 19

Indentation is greater than half the nucleus without any thread-like filaments

Question 20

What is a synonym for segmented neutrophil?

Answer 20

Polymorphonuclear

Question 21

What WBC cell type has the highest percentage in the peripheral blood?

Answer 21

Segmented Neutrophils

Question 22

What is the primary function of a segmented neutrophil?

Answer 22

Functions as a phagocyte

Question 23

How many segments/lobes does a segmented neutrophil have?

Answer 23

2-5

Question 24

What is neutrophili, and during what conditions does it occur?

Answer 24

An increase in circulating neutrophils

Cause by inflammation/bacterial infections

Question 25

How many segments/lobes does an eosinophil have?

Answer 25

2 lobes

Question 26

Duri g what disease states would you expect to see increased eosinophils in peripheral blood ?

Answer 26

Allergic reactions and parasitic infections

Question 27

What three agents are contained in the granules of basophils that may play a role in some acute allergic reactions?

Answer 27

Perioxidase, histamines, and heparin

Question 28

List the three cell types that are identified as agranulocytosis.

Answer 28

Lymphocytic series Plasmacytic series Momocytic series

Question 29

In order from most immature to later, list the maturation sequence of lymphocytes

Answer 29

Lymphoblast Prolymphocyte Lymphocyte