Deck 11 Flashcards
Equation for flow (Q) in relation to pressure and radius?
Q = P1-P2/R
R = viscosity of blood x length of blood vessel/ r^4
Short-hand is Flow = r^4
What blood disorder results in high MCHC?
spherocytosis
Which cytokine is associated with giant cell arteritis?
IL-6 (acute phase inflammatory cytokine)
What is medical tx for GCA?
Tocilizumab (IL 6 monoclonal antibody)
What substance is the “central regulator of iron homeostasis?”
Hepcidin- acute phase reactant
What is action of hepcidin?
Interacts with a transmembrane protein in enterocyte called ferroportin, and inhibits iron absorption in enterocytes
Also inhibits release of iron by macrophages
What raises hepcidin? What lowers it?
Inflammation and high iron levels increase it
Hypoxia and erythropoeisis decrease it
Which cells secrete hepcidin?
Hepatic parenchymal cells
What type of drugs are preferentially metabolized by the liver?
Lipophilic drugs with high Vd
What are SE of first-generation antihistamines?
Anticholinergic symptoms from acting as antagonist to muscarinic acetylcholine receptors. Flushed cheeks and dilated pupils (heat dissaption)
What are clotting labs and seromarkeres for anti-phospholipid antibody syndrome?
Prolonged aPTT False + RPR and VDRL Anticardiolipin Antibody Anti-beta2-glycoprotein-I-atibody \+ lupus anticoagulation
How do beta blockers help treat hyperthyroidism?
Cardiac effects
Inhibited conversion of T4 to T3 by inhibiting 5’ monodeiodinase in peripheral tissues
Which drugs inhibit conversion of T4 to T3?
Propylthiouracil
B blockers
Ipodate
How do propylthiouracil and methimazole work?
Inhibit thyroid peroxidase
Man with infertility, long lower extremities, gynecomastia, and small testes. What does he have?
XXY kienfelters
Decreased testosterone, zero sperm count
