Definitions #2 Flashcards Preview

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Flashcards in Definitions #2 Deck (20)
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1

Neurite

cytoplasmic process of a neurone e.g. axons + dendrites

2

Filopodia

thin membrane protrusions that acts as antennae for cell to probe surrounding environment

3

Name the three parts of the axonal growth cone.

~ central domain
~ transitional zone
~ peripheral domain

4

Neuroplexins

single transmembrane receptors that work as dimers + need co-receptor plexus as don't have signal transduction system

5

Plexins

co-receptors to neuroplexins that trigger novel signal transduction pathway that controls repulsion (cause microtubule disassembly + actin depolymerisation = growth cone collapse)

6

Semaphorin 3

secreted by ventral part of dev. spinal cord to repel thermoreceptor + pain receptors neurites, sensory muscle neurones not affected

7

SAMs

a.k.a. substrate adhesion molecules
important extracellular matrix adhesion molecules

8

Agrin

causes clustering of Ach receptors

9

ARIA

causes production of new Ach receptors

10

Cerebral cortex

outer layer of cerebrum composed of folded grey matter

11

Radial glial

microglial cells that attach their processes to different surfaces forming a scaffolding upon which other cells migrate

12

Name 4 functions of cerebral cortex.

1) personality
2) planning + organisation
3) processing sensory info
4) intelligence

13

Name the 6 layers of cerebral cortex.

1) molcular layer
2) external granular
3) external pyramidal
4) internal granular
5) internal pyramidal
6) fusiform

14

Reelin

an extracellular matrix-associated glycoprotein secreted by Cajal-Retzius cells

15

Cajal-Retzius cells

marginal zone cells that have ascending processes that contact the pial surface and a horizontal axon pleus + secrete reelin

16

Lissencephaly

~ brain surface is smooth due to failure of neural migration
~ severe neurological impairments + intractable seizures

17

Pachygyri

~ where the convolutions of the brain surface are broad, shallow and reduced in number due to a migrational defect
~ severe neurological impairments + intractable seizures

18

Polymicrogyria

~ numbers small gyri due to neuronal migrational interference
~ moderate-severe neurological impairments depending on extend of malformation

19

Cortical heterotopias

~ islands of neurons in abnormal locations due to migrational arrest
~ extend of heterotopia determines degree of neurological impairment + seizures

20

GAL4/UAS system

a method for activating gene expression in Drosophila