Definitions #3 Flashcards Preview

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Flashcards in Definitions #3 Deck (20)
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1

Morula

~ formed by cell division of zygote on day 4
~ secrete fluid and outermost cells become tightly bound together (compaction) --> blastula

2

Radial symmetry

symmetry around a central axis

3

Ectoderm

~ outside layer
~ forms skin, hair, nails, lens of eye, pituitary + mammary glands + ALL CNS

4

Mesoderm

~ middle layer
~ forms muscle, bones, lymphatic tissue, heart + lungs

5

Endoderm

~ inside layer
~ forms lining of lungs, tongue, urethra, bladder + digestive tract

6

What complex degrades Beta-catenin?

axin/GSK-3/APC destruction complex

7

Fizzled

receptor that promotes the activity of the protein dishevelled

8

Dishevelled

inhibits formation of axin/GSK-3/APC destruction complex

9

Which transcription factors promote transcription of the siamois and twin genes?

Beta-catenin + TCF3

10

Siamois and twin genes

act as transcription factors that promote expression of organiser genes w/in spemman's organiser

11

Primitive groove

a depression w/in the primitive streak

12

BMPs

a.k.a. bone morphogenetic proteins
~ belongs to the Transforming Growth Factor-β (TGF-β) superfamily
~ involved in embryogenesis and bone growth

13

FGF

a.k.a. fibroblast growth factors
brings about neurulation in ectodermal cells

14

Fruitless

~ 1st regulatory gene responsible for male-courtship behaviours in flies
~ it retains male-specific circuits that die in females

15

cVA

binds to Lush (protein) which opens ion channels = increased frustration expression

16

Axonal growth cone

found at leading end of growing neurite and responds to different combinations of chemotropic molecules

17

Chemotropic molecules

diffusible + act over long distances (chemoattractants/repellants)

18

Netrins

~ made by floor plate of dev. spinal cord
~ chemoattractant that guides dev of commissural neurones

19

Commissural neurons

~ repelled by BMPs in dorsal spinal cord
~ attracted by netrins in floor plate of spinal cord

20

Ephrins + EPH receptors

repel migrating axon and cause growth cone collapse