Flashcards in Degenerative Diseases Deck (10):
Affects: lesions develop in CNS.
Cause: Unknown; viral and autoimmune possible
Factors: precipitated by stress/ infections/ trauma, worsened by heat, dehydration, fatigue
Most common type of MS
Relapsing-remtting: 85%. Characterized by attacks then full or partial recovery for weeks or months.
Difference between primary and secondary progressive MS?
Primary progressive is progressive from the start with no episode of remitting. Secondary progressive starts as relapse-remitting.
Affects: CNS, degeneration of dopaminergic neurons at substantial nivea basal ganglia. Loss of inhibitory dopamine leads to excessive excitatory output of acetylcholine
Cause: infection, atherosclerosis, idiopathic, toxic, drug-induced
Factors: rigidity, bradykinesia, resting tremor, impaired postural reflexes
Parkinson's Stages (Hoehn and Yahr)
I. Minimal or absent disability, unilateral symptoms
II. Minimal bilateral involvement.
III. Balance is involved, some activity restrictions.
IV. All symptoms present and severe, stands and walks with assistance.
V. Confined to bed or wheelchair.
Levodopa/ carbidopa: provides dopamine
Lasts about 2-3 years until deterioration occurs and dyskinesias may develop.
Control tremor associated with PD
What drug is used early to slow progressions of PD?
MOI, increase dopamine
Affects: PNS, acetylcholine receptors at NM junction
Causes: autoimmune antibody mediated
Factors: usually attacks bulbar (extra ocular, facial and mastication) and proximal limb-girdle muscles. worsens with continued mm contraction