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Flashcards in Dentinogenesis Deck (10)
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dentinogenesis is a continuous process occuring throughout life and more dentine is deposited when there is an external stimulus, but what causes dentinogenesis to stop?

pulp removal/ tooth loss

NB. as more dentine is laid down throughout life, pulp size decreases


dentine and enamel are hard tissues. where does their formation begin and in which direction does it continue

begins at cusp tips/ incisal edge
continues cervically


when does dentinogenesis begin in the stages of tooth development

the late bell stage


which cells differentiate to become odontoblasts

the OUTER cells of the dental papilla


what triggers pre-odontoblast to differentiate into ondonotblasts

the ameleoblasts- they degrade the basal lamina which sends signals across the basement membrane


what happens to the basement membrane once dentine if formed

it disappears


what direction do odontoblasts move as they deposit dentine

odontoblast deposit dentine, and move DOWNWARDS towards core of dental papilla
ameoloblasts deposit enamel and move upwards towards the core of enamel organ


what processes exist in odontoblast and what processes exist in ameleoblasts allowing them to create their respective matrixes

odontoblasts= have odontoblast processes. very long.
ameleoblasts= have tomes processes


describe the stages of dentinogensis

1. central cells of dental papilla in close contact with the basement membrane diffrentiate to become pre-odontoblasts
2. pre-odontoblasts diffrentiate to become odontoblasts
3. odontoblasts have bigger size, more golgi, more ER
4.the ameleoblast degrades the basal lamina, sends inductive signals to the odontoblast
5. the odontoblast nucleus moves to base of cell now, the odontoblast processes develop= lay down the dentine matrix
6. the 1st formed dentine/ the initial layer of mineralisaition is called mantle dentine


how many odontoblast processes are in the odontoblast

initially, there are many, but the rest disappear and only one becomes dominant