Depersonalisation Flashcards

(33 cards)

1
Q

What is depersonalisation

A

Alteration in the perception or experience of the self so that one feels detached from an as if one is an outside observer of ones mental process or body (DSM IV)

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2
Q

What is DPDR

A

Strange and disturbing sense of unreality in ones experience of oneself (DP) and ones surroundings (DR)

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3
Q

What are the five major domains in DPD?

A

Depersonalisation
Derealisation
Desomatisation
De-affectualisation
Deideation

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4
Q

Depersonalisation

A

Being separate from oneself; observing oneself as if from outside; feeling like a robot

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5
Q

Derealisation

A

Threatening sense of unfamiliarity or unreality in the environment; others feels like actors

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6
Q

Desomatisation

A

Loss or alteration of bodily sensations; sense of disembodiment; raised pain threshold

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7
Q

Deaffectualisation

A

Loss of emotional reactivity; emotions feel like they lack spontaneity and subjective validity; may affect intimate relationships

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8
Q

Deideation

A

Difficulty concentrating; cotton wool head

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9
Q

Treatment modalities (SLaM)

A

Cognitive behavioural therapy
Pharmacotherapy with lamotrigine (monotherapy vs combination therapy with an SSRI)

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10
Q

Clinical ax

A

Hx including the nature of episodes (episodic/ intermittent); associated sx; clinical ax scales

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11
Q

What are the differentials for DPD

A

Temporal lobe epilepsy
Anxiety
Depression
Psychosis

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12
Q

What investigations should be carried out in DPD?

A

CT/MRI
Blood tests inc. thyroid function

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13
Q

Cambridge depersonalisation scale

A

29-item scale self rated scale
Assesses experiences in the last 6 months
Scores experiences based on frequency and duration
Each item can score a max of 10 points

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14
Q

DPD and anxiety

A

Hx of anxiety/ panic attacks
Comorbid anxiety

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15
Q

Pharmacological mx of DPD

A

Lamotrigine (monotherapy or combination therapy with an SSRI)
Clonazepam
Naltrexone
Clomipramine
Psychostimulants e.g methylphenidate, modafinil)

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16
Q

Lamotrigine for DPD

A

Reduces excitatory amino acid transmission, mainly glutamate
Blocks sodium channels
Stabilises neuronal membrane
Blocks NMDA receptor ketamine related DPDR
Effective to reduce DP sx in combination therapy

17
Q

Non pharmacological mx

A

CBT
Attentional training e.g mindfulness
Repetitive transcranial magnetic stimulation to right ventrolateral prefrontal cortex

18
Q

CBT - diary entries for chronic sx

A

Hourly dairy entries rated from 0-10 based on severity

19
Q

CBT - diary entries for infrequent sx

A

Record the situation
Rate the severity
Duration
Mood
Thoughts
Behaviour

20
Q

How do we analyse diary entries?

A

Analyse for fluctuations
Organise by worse vs better
Consider underlying mechanisms
Schedule activities based on diary entries
Helps to highlight role of anxiety and low mood

21
Q

Grounding strategies for DPD?

A

Grounding strategies aim to refocus a persons attention on the present using:
- surroundings
- words/ statements
- image
- posture
- objects
- focus on each of the senses

Need to use them ASAP when symptoms start coming on

22
Q

How do we deal with unhelpful thoughts in DPD

A

Challenge negative automation thoughts with counter evidence

23
Q

Thinking process focused CBT interventions for DPDR

A

Strategies that reduce rumination and worry
Understanding and manipulation sx focused attention

24
Q

Behaviour focused CBT interventions for DPDR

A

Weigh the pros and cons of checking behaviours
Avoid avoidance by graded exposure to old activities

25
FMRI to probe emotional experience
Aversive vs neutral images from the international affective picture system Anterior insula activation to aversive stimuli in controls vs pt
26
Which area is associated with suppression of emotional response
Right ventral prefrontal cortex Area BA47
27
The role of the insula
Integrates bodily feedback into awareness Involved in the normal response to aversive stimuli
28
Effect of lamotrigine tx
5/10 report clinically significant improvement Pt who respond to lamotrigine show more left anterior insula and visual cortex activation at 6 months vs pt who didn’t respond to lamotrigine
29
Neural activation in response to aversive/ emotional stimuli
Controls show activation in right anterior insula and occipital visual cortex compared to pt
30
Pre vs post tx activation in the right prefrontal cortex
All DPD pt show activation in right ventromedial prefrontal cortex (Brodmann area 47) At time 2 post tx pt who don’t response show activations in bilateral visual areas and right prefrontal cortex
31
Milder depersonalisation sx are seen in which other conditions
EUPD PTSD Schizophrenia
32
Dx criteria for EUPD
Chronic feelings of emptiness
33
DP vs schizophrenia
Basic symptoms - DP DR Are distinct from positive and negative sx of schizophrenia - occur in prodromal sz