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M R C P > derm > Flashcards

derm Flashcards

1
Q

Tx erythema nodosum

A

NSAIDS

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2
Q

resp infections associated with what type of vasculitis

A

Henoch schonlein purpura HSP

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3
Q

Ix HSP

A

AUTOANTIBODIES- ANCA, ANA, RF
Bloods- FBC, renal, CXR- for pulmonary involvement

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4
Q

Mx HSP

A

rest, analgesia
SEVERE cases- corticosteroids/immunosuppressants

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5
Q

what skin condition associated with coeliac disease

A

dermatitis herpetiformis

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6
Q

what skin condition is DAPSONE used to treat

A

dermatitis herpetiformis

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7
Q

most common type of skin drug reaction

A

TOXIC ERYTHEMA

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8
Q

NAME the 3 types of erythema multiforme in order of severity

A

least
Erythema multiforme
-Stevens-Johnson syndrome
-Toxic epidermal necrolysis
MOST

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9
Q

what does erythema multiforme look like

A

target lesions

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10
Q

 Prodrome of fever, weakness, respiratory symptoms
 Typical target-shaped lesion
 Red/pink macules > papules > plaques > darkening (purpuric), blistering/crusting
 Lesions may begin on backs of hands/feet > progress proximally
 Always affects mucosal sites - commonly lips/tongue/cheeks, also conjunctivae and others

A

SJS

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11
Q

Toxic epidermal necrolysis:

A

 Widespread erythema, then significant necrosis + detachment of epidermis (>30% of body area)
 Mucosal, respiratory and GI involvement
 7-21 days initiation
 ~30% mortality
 1000x increased risk in HIV+
 Causes:
o Drugs - penicillin, sulphonamides, NSAIDs, allopurinol, anticonvulsants
 Management:
o Burns unit/ITU
o Withdraw offending drug
o Hydration
o Nutritional support
o Short term dexamethasone, IV immunoglobulin

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12
Q

Antibodies against desmoglein 3 are seen in ????

A

pemphigus vulgaris

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13
Q

Pityriasis versicolor is caused by

A

Malassezia furfur

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14
Q

typically affects nose, cheeks and forehead
flushing is often first symptom
telangiectasia are common
later develops into persistent erythema with papules and pustules
rhinophyma
ocular involvement: blepharitis
sunlight may exacerbate symptoms/

A

acne rosacea

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15
Q

keloid scars common in?

A

young black males

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16
Q

keloid treatment

A

intra-lesional steroids e.g. triamcinolone

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17
Q

what medication exacerbates plaque psoriasis

A

beta blocker propanolol

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18
Q

what causes eczema herpeticum

A

MOST common: HSV1+2
Rarely coxasackie

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19
Q

bullous pemphygoid vs pemphigus vulgaris

A

mucosal involvement in pemphigus VULGARIS

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20
Q

renal transplant skin ca risk

A

SCC

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21
Q

scabies management

A

permethrin 5% is first-line
malathion 0.5% is second-line

normal for pruitus 6-8 weeks after treatment

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22
Q

Acne vulgaris in pregnancy treatment

A

oral erythromycin

23
Q

deficiency of what causes pellagra

A

niacin deficency- comes from nicotinic acid

24
Q

which mineral and which vitamin deficiency causes angular chelitis?

A

ZINC
vit b2 riboflavin

25
Q

pityriasis rosea causative organism

A

Herpes hominis virus 7 (HHV-7)

26
Q

pityriasis versicolor treatment

A

ketoconazole shampoo (NOT cream)

27
Q

acne rosacea treatment

A

moderate: topical ivermectin (other- metronidazole)
severe: oral doxy and ivermectin

28
Q

bullous pemphygoid treatment

A

oral corticosteroid

OID– sterOID oral

29
Q

skin ca associated with pUVA therapy

A

SCC

30
Q

lichen planus first line management

A

topical steroids

31
Q

Pemphigoid gestationis vs Polymorphic eruption of pregnancy
and their treatments

A

Polymorphic eruption of pregnancy: no blisters Tx= emollients, mild potency topical steroids and oral steroids may be used
looks MORE WIDESPREAD and bitty

pehmphygoid gestationis; blistering, peri umbilical
Tx= oral corticosteroids are usually required

32
Q

which psych med worsens psoriasis

A

lithium

33
Q

photosensitive rash with blistering and skin fragility on the face and dorsal aspect of hands

hypertrichosis
hyperpigmentation

A

Porphyria cutanea tarda

34
Q

Ix Porphyria cutanea tarda

A

urine: elevated uroporphyrinogen and pink fluorescence of urine under Wood’s lamp
serum iron ferritin level is used to guide therapy

35
Q

management porphyria cutanea tarda

A

chloroquine
venesection

36
Q

dermatitis artefacta

A

Linear, well-demarcated skin lesions that appear suddenly, with ‘la belle indifference’
pts doing it them self- self harm

37
Q

wood-grain’ pattern and figurate erythema commonly seen in patients with lung cancer

A

Erythema gyratum repens

38
Q

meds causing erythema nodosum

A

COCP
sulphonamides
penicillins

39
Q

treatment MRSA impetigo golden crust

what orgs cause impetigo

A
  1. fusidic acid
  2. mupirocin

caused by
staph aureus or strep pyogenes

40
Q

fir tree appearance

A

fir tree
Pityriasis rosea

41
Q

Porphyria cutanea tarda
cause
CFs
Ix
Tx

A

most common hepatic porphyria. It is due to an inherited defect in uroporphyrinogen decarboxylase or caused by hepatocyte damage e.g. alcohol, hepatitis C, oestrogen.

CFs
photosensitive rash with blistering and skin fragility on the face and dorsal aspect of hands
hypertrichosis
hyperpigmentation

Investigations
urine: elevated uroporphyrinogen and pink fluorescence of urine under Wood’s lamp
serum iron ferritin level is used to guide therapy

Management
chloroquine
venesection
preferred if iron ferritin is above 600 ng/ml

42
Q

topical steroid strength

A

Topical steroids
moderate: Clobetasone butyrate 0.05%
potent: Betamethasone valerate 0.1%
very potent: Clobetasol propionate 0.05%

43
Q

systemic mastocytosis

CFs
diagnosis

A

Features
urticaria pigmentosa - produces a wheal on rubbing (Darier’s sign)
flushing
abdominal pain
monocytosis on the blood film

Diagnosis
raised serum tryptase levels
urinary histamine

44
Q

which viruses )numbers) cause eczema herpeticum

A

HSV 1 AND 2

45
Q

dermophyte nail fungal infection treatment

A

PO terbinafine 12 weeks

46
Q

irritant contact dermatitis VS allergic contact dermatitis:

A

allergic contact dermatitis:
common
not allergy
caused by hair dyes

allergic contact dermatitis:
type 4 hypersensitivity reaction
more uncommon

47
Q

causative drugs SJS

A

COCP
sulphonamides- co trimoxazole
penicillin
lamotrigine, carbamazepine
allopurinol
NSAIDs

48
Q

caused by IgA deposition in the dermis

A

dermatitis herpetiformis

49
Q

‘wood-grain’ pattern, lung ca

A

Erythema gyratum repens

50
Q

Dermatitis in acral, peri-orificial and perianal distribution– deficiency of what??

A

ZINC

51
Q

which antibiotic can cause irreversible skin hypopigmentation

A

minocycline

52
Q

bullous pemphygoid antibodies

vs

pemphigus vulgaris

A

Hemidesmosomal BP antigens

pemphigus vulgaris = desmoelgein 3

53
Q

Severe vit a toxicity caused by retinoids in psoriasis cfs

A

bilateral pappiloedema

54
Q

pemphigus vulgaris treatment levels

A
  1. prednisolone
    if no response- immunosuppresion with
    RITUXIMAB

M R C P (18 decks)

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