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Pathology 1st aid > Derm Path > Flashcards

Derm Path Flashcards

1
Q

Excessive Fibrosis and collagen deposition

absence of wrinkles

puffy/taut skin

A

Scleroderma

Systemic Sclerosis

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2
Q

Scleroderma seen in what organ systems other than derm?

A

Renal
Pulmonary
Cardio
GI

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3
Q

COD of scleroderma

A

Pulmonary fibrosis/collagen deposition

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4
Q

Scleroderma with:
Widespread skin involvement
rapid progression
early visceral involvement

A

Diffuse Scleroderma

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5
Q

Diffuse Scleroderma Ab

A

Scl-70 Ab

anti-DNA topoisomerase I Ab

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6
Q

CREST Syndrome

A 
Calcinosis
Raynaud's
Esophageal dysmotility
Sclerodatyly
Telangiectasia

Limited skin involvement to face/fingers

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7
Q

CREST syndrome Ab

A

anti-Centromere

C for CREST

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8
Q

Thickening of stratum corneum

A

hyperkeratosis

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9
Q

hyperkeratosis with retention of nuclei in stratum corneum

A

parakeratosis

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10
Q

separation of epidermal cells

A

acanthylosis

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11
Q

epidermal hyperplasia of spinosum

A

acanthosis

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12
Q

Melasma

A

hyperpigmentation of pregnancy

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13
Q

Vitiligo

A

Irregular areas of complete depigmentation

DECREASED # of MELANOCYTES

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14
Q

Albinism

A

NORMAL # OF MELANOCYTES

Decreased melanin production due to decreased TK activity

Failure of neural crest cells to migrate

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15
Q

Koilocytosis
Epidermal hyperplasia
hyperkeratosis

soft tan colored cauliflower-like papules

A

Verrucae

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16
Q

Verrucae cause

A

HSV

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17
Q

Condyloma accuminata

A

Genital warts

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18
Q

Melanocytic Nevus

A

Mole

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19
Q

Papular mole

A

Intradermal nevus

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20
Q

flat macule (mole)

A

Junctional Nevus

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21
Q

Urticaria

A

Wheals after mast cell degranulation

Hives

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22
Q

Ephelis

A

Freckle

Normal # of melanocytes
Inc. melanin

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23
Q

Atopic Dermatitis

A

Eczema

face during infancy
Antecubital fossa

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24
Q

Linear rash

A

Allergic Contact dermatitis

Type IV hypersensitivity

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25
Papules and plaques with silvery scaling knee/elbows Acanthosis with parakeratotic scaling
Psoriasis Increased spinosum Decreased granulosum
26
Auspitz sign
Pinpoint bleeding from dermal paplillae exposed when scales scraped off psoriasis finding
27
Flat, greasy pigmented squamous epithelial proliferation Keratin Filled Cysts Head, trunk, extremities
Seborrheic Keratosis
28
Leser-Trelat Sign
Sudden appearance of multiple seborrheic keratoses Indicative of underlying malignancy (GI, Lymph)
29
Nikolsky's Sign
separation of epidermis upon manual stroking of skin
30
Pemphigus Vulgaris
IgG Ab against DESMOGLEIN 3 of desmosomes Acantholysis intraepidermal bullae --> flaccid blister IF: Ab around epidermal cells in reticular/netlike pattern Positive Nikolsky's Sign INVOLVES ORAL MUCOSA can be fatal
31
Bullous Pemphigoid
IgG against HEMIDESMOSOMES in epidermal basement membrane Negative Nikolsky SPARES ORAL MUCOSA Tense blisters
32
IgA deposits at tips of dermal papillae pruritic papules, vesicles, bullae Celiac Sprue
Dermatitis Herpetiformis
33
Multiple lesion types--macules, papules, vesicles, target lesions
Erythema Multiforme
34
Erythema Multiforme associated with
Infections Rx Cancer autoimmune
35
Fever bulla formation sloughing of skin high mortality rate associated with Rx Rxn
Stevens-Johnson Syndrome
36
Stevens-Johnson Syndrome that comvers >30% of body
Toxic Epidermal Necrolysis
37
symmetrical hyperpigmented velvety thickening of skin on neck or axilla Epidermal hyperplasia
Acanthosis Nigracans
38
Acanthosis Nigracans associated with
Hyperinsulinemia (diabetes, obesity, Cushing's Syndrome) Visceral malignancy
39
Premalignant lesion from sun exposure small, rough, erythematous/brown papules or plaques
Actinic Keratosis
40
Actinic Keratosis increased risk of
Squamous Cell CA Proportional to degree of dysplasia
41
Inflammatory lesions of Sub-Q fat
Erythema Nodosum
42
Erythema Nodosum associated with
``` Sarcoidosis Coccidiodomycosis histoplasmosis TB/Leprosy Strep Crohn's ```
43
Pruritic, purple, polygonal planar paplules and plaques Sawtooth infiltarte of lymphocytes at dermal-epidermal jnx
Lichen Planus
44
Lichen Planus associated with
HCV
45
Heral Patch --> Christmas Tree light pattern days later Multiple plaques iwth collarette scale
Pityriasis rosea
46
UV rays and effects of skin
UVA--tanning and photoaging UVB--Sunburn --> cancers
47
Cancers associated with sunburn
Basal Cell CA Sq. Cell CA Melanoma
48
Impetigo bugs
S. aureus | Strep pyogenes
49
Bullous impetigo bug
Staph aureus
50
Acute painful spreading infxn of dermis and Sub-Q tissues
Cellulitis Staph aureus Strep pyogenes
51
Crepitus at lesion Deep dissue injury bullae and purple color pain out of proportion with lesion
Necrotizing Fasciitis
52
Necrotizing Fasciitis bugs
anaerobics | S. pyogenes
53
What causes crepitus with Necrotizing Fasciitis?
methane and CO2 production of bacteria eating tissue
54
Fever Geralized erythematous rash with sloughing of upper layers of dermis no scars
Staph Scalded Skin Syndrome Staph Aureus
55
Pathophys of SSSS
Exotoxin destroys keratinocyte attachments in stratum granulosum only
56
White, painless plaques on tongue that cannot be scraped off HIV+
Hairy Leukoplakia EBV mediated in IC pts.
57
#1 skin cancer
Basal cell CA
58
``` Palisading nuclei pink pearly nodules telangietasias rolled borders crusting ulcerations Non-Healing ulcer or scaling plaque ```
Basal Cell CA Sun exposed area
59
Spread of Skin Cancers
BCC and SCC rarely metastasize Melanom--mets to distant areas
60
Keratin Pearls Ulcerative red lesions with frequent scale Sun exposed areas
Squamous Cell CA of Skin
61
Keratoacanthoma
Variant of SCC of skin regresses spontaneously rapid growth over 4-6 weeks
62
Squamous Cell CA of skin precurser
Actinic Keratosis
63
Melanom Tumor marker
S-100
64
Melanoma risk of mets determined by
Depth of invasion
65
Melanoma mutation
BRAF Kinase
66
Vemerafenib
BRAF Kinase inh. used for BRAF V600E melanoma

Pathology 1st aid (11 decks)

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