Development Of The Kidneys Flashcards

1
Q

Wolffian ducts

A

Precursor of male internal sex organs

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2
Q

Mullerian ducts

A

Precursors of female internal sex organs

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3
Q

What part of the wolffian duct does not degenerate in females

A

Lower portion - forms ureteric bud

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4
Q

What are the 3 embryonic kidneys

A

Pronephric
Mesonephric
Metanephric

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5
Q

What duct do the kidneys form from

A

Mesonephric

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6
Q

What is the only functional embryonic kidney

A

Metanephric kidney

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7
Q

What 2 embryonic structures form the Metanephric kidney

A

Uteteric bud
Metanephric bud

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8
Q

What adult structures form from the ureteric bud

A

Ureter
Renal pelvis
Major and minor calyces
Collecting tubules

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9
Q

What adult structures form from the Metanephric bud

A

Renal glomerulus + capillaries
Bowman’s capsule
Proximal convoluted tubule
Loop of henle
Distal convoluted tubule

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10
Q

What does the kidney collecting system form from

A

Ureteric bud

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11
Q

What does the nephron form from

A

Metanephric bud

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12
Q

Do the adrenal glands ascend

A

No - develop in situ

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13
Q

Where does the Metanephric kidney develop

A

S1

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14
Q

What happens to the transitory renal arteries

A

Degenerate

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15
Q

What does a failure of the kidneys to ascend cause

A

Ectopic kidney

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16
Q

What is the most common cause of kidney agenesis

A

Failure of uteric bud to meet mesenchyme

17
Q

Kidney agenesis

A

Failure of 1/both kidneys to form

18
Q

What type of kidney agenesis is asymptomatic

A

Unilateral

19
Q

Oligohydramnios

A

Reduction in amniotic fluid

20
Q

Why does bilateral renal agenesis lead to oligohydramnios

A

Kidneys involved in generation of amniotic fluid

21
Q

How does bilateral kidney agenesis lead to failure of lung development

A

Decreased amniotic fluid

22
Q

Bifid ureter

A

Ureter splits in 2

23
Q

What can a bifold ureter lead to

A

Duplicate kidneys
Duplicate ureter

24
Q

Ectopic pelvic kidney

A

Kidney remains in pelvic region

25
Pancake kidney
Both poles of kidneys fuse creating 1 very large kidney in pelvic region with normal function
26
Pancake kidney symptoms
Asymptomatic
27
Horseshoe kidney
Kidneys fuse at 1 pole in pelvic region forming a single u shaped kidney
28
Why can horseshoe kidneys not ascend
Blocked by inferior mesenteric artery
29
Polycystic kidney
Kidney develop fluid filled cysts
30
What causes polycystic kidneys
Defects in formation of tubules of nephron
31
What mutation is the majority of polycystic kidney disease cases associated with
PKD-1
32
How does a kidney cyst form
Dilation of tubule -> proliferation of cyst epithelium -> cyst epithelium becomes secretory -> fluid secretion into cyst lumen -> cyst enlarged and loses contact with nephron