Developmental Pharmacology

Question 1

Drug used for caesarean sections

Answer 1

Thiopental

Question 2

An ionized but highly lipophilic drug

Answer 2

Salicylate

Question 3

Anti-coagulant given to pregnant mothers

Answer 3

Heparin

Question 4

Moleculle that can cross the placenta even if they are very large

Answer 4

Maternal antibody

Question 5

Some drugs with greater affinity for maternal rathen than fetal

Answer 5

Sulfonamides
Barbiturates
Phenytoin
Local anesthetics

Question 6

Interferes with normal maturation & function

Answer 6

Hadegen

Question 7

Agent that alters growth

Answer 7

Trophogen

Question 8

Examples of basoc drugs

Answer 8

Lidocaine
Beta blocker
Tricyclic anti-depressanta

Question 9

Immediate fetal drug thay induces limb deformities

Answer 9

Thalidomide

Question 10

Immediate fetal drug that can cause craniofacial, cardiac, CNS defects

Answer 10

Retinoic acid

Question 11

Produces phocomelia

Answer 11

Thalidomide

Question 12

Hydrocephalus

Answer 12

Valproate

Question 13

E: cleft lip/palate

Answer 13

Phenytoin

Question 14

E: masculinization in female fetus

Answer 14

Androgen, progestin

Question 15

E:craniofacial abnormalities

Answer 15

Ethanol

Question 16

DELAYED E: affects bone growth

Answer 16

Tetracycline

Question 17

Delayed E: non-ateroidal estrogen used for vaginitia and some menopausal syndromes

Answer 17

Diethylstilbestrol

Question 18

DE: Teeth staining

Answer 18

Tetracycline

Question 19

DE: Adenocarcinoma of the vagina and genital malformations

Answer 19

Diethystilbestrol

Question 20

DE: learning disabilities

Answer 20

Ethanol, cocaine

Question 21

Categpry B drugs

Answer 21

Amoxicillin, cefuroxime, loratadine

Question 22

Category C drugs

Answer 22

Acyclovir, fluconazole, metoprolol

Question 23

Category D

Answer 23

Benzodiazepine

Question 24

Category X

Answer 24

Warfarin, diethylstilbestrol, methotrexate

Question 25

Lactating mom E: teeth staining

Answer 25

Tetracyclin

Question 26

Lactating mom E: kernicterus

Answer 26

Sulfonamide

Question 27

Lactating mom E: gray baby syndrome

Answer 27

Chloramphenicol

Question 28

Lactating mom E: pyridoxine deficiency

Answer 28

Isoniazid

Question 29

Lactating mom E: lethargy, sedation, poor suck reflex

Answer 29

Barbiturates

Question 30

Lactating mom E: sedation

Answer 30

Chloal hydrate

Question 31

Lactating mom E: sedation, drug accumulation

Answer 31

Diazepam

Question 32

Lactating mom E: narcotic independence

Answer 32

Opioids

Question 33

Lactating mom E: fetal alcohol syndrome

Answer 33

Alcohol

Question 34

Lactating mom E: breast milk conc = maternal serum conc

Answer 34

Lithium

Question 35

Lactating mom E: low birth wt, mental retardation

Answer 35

Nicotine

Question 36

Lactating mom E: thyroid suppression, thyroid cancer

Answer 36

Eadioactive substances