Pediatrics Pharmacology Flashcards
(25 cards)
Glucuronide formation reaches adult values at
Age 3-4
T/F. Neonates have slower clearance and prolonged elemination half-lives
True
T/F. If mom is receiving drugs, chances are neonates will not be able to metabolize durgs faste
False
T/F. Toddles have the highest metabolism rate
True
Mother has lack of milk, infant becomes dehydrated causing hyperbilirubinemia
Breastfeeding jaundice
Breastmilk jaundice
Mother’s breastmilk has high glucuronidase
GFR and renal plasma flor have increased 50% from day 1
1 wk old
GFR 50-60%
3 wk old
GFR reaches adult value
6-12 mos old
Exceeds drug metabolism
Tiddlerhoid
30-40% adult GFR
Newborn
Unique factors influencing drug absorption
Blood flow
GI function
GI secretion og neonate starts
Soon after birth
GI secretion of premies is highes on
4th day of life
Gastric emptying is prolonged up to
6-8 hrs in the first day of life
Oral abs of these drugs is increased
Ampicillin, penicillin
Oral abs of these drugs is decreased
Acetaminophen
Phenobarbital
Phenytoin
Oral abs of these drugs is normal
Diazepam
Digoxin
Sulfonamide
Who has higher body water, neonate or adult
Neonate > adult
Who has higher body water preterm infant or neonate
Preterm > neonate
Most neonates experience diuresis eithin
24-48 hrs
Who has higher total body preterm or neonate
Premie
This drug displaces bilirubin
Sulfonamide
This drug is displaced by bilirubin
Phenytoin
