Drug Discovery

Question 1

Traditional meds for beart ailments

Answer 1

Foxglove: digitalis glycoside

Question 2

Traditional med used as NM relaxant

Answer 2

Curare: tubocurarine

Question 3

Traditional meds for pain relief

Answer 3

Opium poppy: opiates

Question 4

Traditional meds for diabetes now used in cancer therapy

Answer 4

Periwinkle: vincas

Question 5

Med accidentally discovered for mania

Answer 5

Lithium

Question 6

Med accidentally discovered for psychosis

Answer 6

Chlorpromazine

Question 7

Med accidentally discovered for bacterial infection

Answer 7

Penicillin

Question 8

Med accidentally discovered for penile dysfunctio

Answer 8

Silldanefil

Question 9

Among Filipinos, 50% of lung cancer is due to

Answer 9

EGFR mutations

Question 10

Examples of EGFR tyrosine kinase inhibitors

Answer 10

Erlotinib
Gefitinib
Afatinib
Osimertinib

Question 11

Examples of EGFR tyrosine kinase inhibitors

Answer 11

Erlotinib
Gefitinib
Afatinib
Osimertinib

Question 12

Examples of Gs receptors

Answer 12

Beta receptors
5-HT
H1

Question 13

Examples of Gi

Answer 13

Presynaptic a2, 5-HT1A

Question 14

Examples of Gq

Answer 14

a1
Postsynaptic a2
M3

Question 15

Examples of RTKs

Answer 15

Insulin R.
EGFR
HER2

Question 16

Ex. of catalytic receptor

Answer 16

Interleukin receptors

Question 17

ACE inhibitors

Answer 17

Enalapril

Captopril

Question 18

Na+ gated channels are inhibted by

Answer 18

Class I anti-arrhythmics
Local anesthetics
Anticonvulsants

Question 19

K+ channels are inhibited by

Answer 19

Class III anti-arrhythmics

Question 20

Ca2+ channels are inhibited by

Answer 20

Class IV anti-arrhythmics

Question 21

Nicotinic receptors stimulated by

Answer 21

ACh

Auccinylcholine

Question 22

Nictonic receptors inhibited by

Answer 22

Non-depolarizing NM blockers
Atracurium
Pancurium

Question 23

GABA A receptor stimulated by

Answer 23

Benzodiazepines (diazepam, midazolam)
Barbituratea
gaba

Question 24

Na/K atpase inhibitor

Answer 24

Digoxin

Question 25

H/K atpase inhibitors

Answer 25

PPIs (-prazoles)

Question 26

Colchicine

Answer 26

Drug for gout

Question 27

Mitotic spindle inhibitors

Answer 27

Vincas, taxanes

Question 28

Dimercaprol

Answer 28

As, Hg, Au, Pb overdose

Question 29

Penicillamine used for

Answer 29

Copper overdose

Question 30

Desferoxamine used for

Answer 30

Fe overdose

Question 31

Example of irreversible drug

Answer 31

Clopidogrel - antiplatelet aggregant