DIABETES AI Flashcards

(42 cards)

1
Q

What are the types of diabetes?

A
  • Type 1 diabetes mellitus
  • Type 2 diabetes mellitus
  • Maturity-onset diabetes of the young (MODY)
  • Latent autoimmune diabetes in adults (LADA)
  • Gestational diabetes mellitus (GDM)
  • Secondary diabetes

MODY is hereditary, LADA is often treated like type 2, and secondary diabetes can occur due to various medical conditions or medications.

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2
Q

Define type 2 diabetes.

A

A chronic condition characterized by the body’s inability to effectively use insulin, leading to high blood sugar levels.

Insulin is produced by the pancreas and helps regulate glucose levels.

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3
Q

What is insulin resistance?

A

When the body’s cells become less responsive to insulin, requiring the pancreas to produce more insulin to maintain stable blood sugar levels.

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4
Q

What is pancreas exhaustion?

A

When the pancreas can no longer keep up with the increased demand for insulin, leading to rising blood glucose levels.

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5
Q

What is hyperglycaemia?

A

Chronically high blood sugar, a hallmark of full-blown type 2 diabetes.

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6
Q

What are some risk factors for type 2 diabetes?

A
  • Genetics
  • Obesity or overweight
  • Inactivity
  • Age
  • Race/Ethnicity
  • Other conditions

Conditions like prediabetes and gestational diabetes also increase risk.

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7
Q

List common signs and symptoms of type 2 diabetes.

A
  • Increased urination
  • Excessive thirst
  • Unexplained weight loss
  • Feeling very tired
  • Blurred vision
  • Slow healing wounds
  • Frequent infections
  • Tingling or numbness in hands and feet
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8
Q

What is the HbA1c diagnostic criterion for diabetes?

A

6.5% (48 mmol/mol) or higher.

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9
Q

What does fasting plasma glucose (FPG) measure?

A

Blood sugar levels after an overnight fast of at least 8 hours.

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10
Q

What are the blood glucose targets before meals for non-pregnant adults with diabetes?

A

4 to 7 mmol/L.

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11
Q

What is the cholesterol target for individuals with diabetes?

A
  • Total cholesterol: < 4 mmol/L
  • LDL cholesterol: < 2 mmol/L
  • HDL cholesterol: > 1 mmol/L in men and > 1.2 mmol/L in women
  • Triglycerides: < 1.7 mmol/L
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12
Q

What is the recommended physical activity for individuals with diabetes?

A

150 minutes per week, including both resistance and cardiovascular training.

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13
Q

What are common medications prescribed for type 2 diabetes?

A
  • Biguanides (e.g., metformin)
  • Sulphonylureas (e.g., gliclazide)
  • Alpha-glucosidase inhibitors (e.g., acarbose)
  • DPP-4 inhibitors (e.g., sitagliptin)
  • SGLT2 inhibitors (e.g., dapagliflozin)
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14
Q

What is the primary action of Biguanides?

A

They increase insulin sensitivity and reduce hepatic gluconeogenesis.

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15
Q

True or False: Alcohol can cause hypoglycaemia.

A

True.

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16
Q

What is the glycaemic index (GI)?

A

A ranking system that measures how quickly carbohydrate-containing foods raise blood sugar levels.

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17
Q

Fill in the blank: The maximum recommended alcohol intake for diabetic patients is _______ units.

18
Q

What are the microvascular complications of diabetes?

A
  • Diabetic retinopathy
  • Diabetic nephropathy
  • Diabetic neuropathy

Neuropathy can lead to peripheral and autonomic nerve damage.

19
Q

What dietary modifications are recommended for managing type 2 diabetes?

A
  • Moderate intake of carbohydrates
  • Promote a low glycaemic index diet
  • Encourage healthy BMI between 20-25 kg/m2
20
Q

What is the ideal body weight formula?

A

Ideal body weight (kg) = height^2 x desired BMI.

21
Q

What is the role of dietary education programmes like DESMOND?

A

To educate and support individuals with diabetes in self-management.

22
Q

List the side effects of Biguanides.

A
  • Nausea
  • Diarrhoea
  • Decreased B12 absorption
  • Lactic acidosis (rare but fatal)
23
Q

What are the signs of hypoglycaemia?

A
  • Sweating
  • Shakiness
  • Confusion
  • Dizziness
  • Hunger
  • Irritability
24
Q

What is the treatment for hypoglycaemia?

A

15-20g of fast-acting carbohydrates (e.g., fruit juice, glucose tablets).

25
What is the significance of the HbA1c test?
It reflects average blood sugar control over the past 2-3 months.
26
What are the benefits of medications like dapagliflozin and canagliflozin?
Offer realistic chance of weight loss and don't cause hypoglycaemia ## Footnote These medications promote glucose excretion and are beneficial for certain patients.
27
What are common side effects of SGLT2 inhibitors?
UTIs ## Footnote Urinary tract infections are a notable side effect associated with SGLT2 inhibitors.
28
What are incretin agonists or GLP-1 receptor agonists used for?
They mimic naturally produced gut hormones, stimulating glucose-dependent insulin secretion and promoting satiety ## Footnote Examples include tirzepatide, semaglutide, and liraglutide.
29
What are the indications for using GLP-1 receptor agonists?
A BMI of >35 kg/m2 ## Footnote These medications are indicated for patients with obesity and related conditions.
30
What are the common side effects of GLP-1 receptor agonists?
Nausea, vomiting ## Footnote These side effects are associated with the use of GLP-1 receptor agonists.
31
What are the cardiovascular benefits of GLP-1 receptor agonists?
Lower hypoglycaemia risk and have cardiovascular benefits in patients with pre-existing cardiovascular disease ## Footnote These medications provide additional health benefits beyond glycemic control.
32
What factors determine an insulin regimen?
Type of diabetes, person's lifestyle, mealtime routine, working hours, age, presence of obesity ## Footnote Insulin therapy must be personalized based on individual circumstances.
33
What are the injection sites for insulin?
Stomach, thighs, upper arm, buttocks ## Footnote The site of injection can affect absorption rates.
34
What is the duration and action time of rapid acting insulin?
Taken 10-15 mins before meals, lasts 2 - 5 hours ## Footnote Examples include aspart and lispro.
35
How long before meals should short acting insulin be taken?
Approximately 30 mins before meals ## Footnote Short acting insulin starts working in 30 mins to 1 hour.
36
What is the duration of action for intermediate acting insulin?
Lasts 8 - 14 hours ## Footnote Intermediate acting insulin is typically taken once or twice per day.
37
How often is long acting insulin taken and what is its duration?
Taken once or twice per day, lasts 18 - 24 hours ## Footnote Long acting insulin provides a stable insulin level throughout the day.
38
What is the composition of intermediate acting insulin?
Mixture of short and long acting insulin ## Footnote This type of insulin is taken two to three times daily before meals.
39
What factors can affect insulin absorption rates?
Exercise, temperature, massage, site chosen ## Footnote The fastest absorption is typically from the stomach.
40
What are common side effects of insulin therapy?
Hypoglycaemia, local allergic reaction, lipohypertrophy ## Footnote These side effects can impact insulin management.
41
What is the indication for bariatric surgery in diabetes management?
Suggested for people with type 2 diabetes and BMI >35 kg/m2 ## Footnote Bariatric surgery can lead to significant health improvements, including diabetes remission.
42
What percentage of patients reported diabetes remission after bariatric surgery according to a meta-analysis?
65% ## Footnote This statistic highlights the potential effectiveness of surgical interventions in diabetes management.