Diabetic Nephopathy - path pt. Flashcards Preview

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Flashcards in Diabetic Nephopathy - path pt. Deck (6):
1

What is the most important stage of Diabetic Nephropathy to be able to identify on Histology?

• how is it identified?

 

Most Important Stage - STAGE III:
NODULAR glomerulosclerosis => KIMMELSTEIL-WILSON NODULES

 

***Note: in stage IV the glomeruli become so sclerotic that you can barely make out the basement membrane***

 

2

What disease resembles Diabetic Nephropathy on histology?

• how do you differentiate these diseases?

Diabetic Nephropathy and Light Chain Disease resemble each other on Histology with Nodular Glomerulosclerosis

 

IMMUNOFLUROSCENCE helps to differentiate between these two things

3

What is shown here?
• what is the green arrow pointing to?
• what is the orange arrow pointing to?
• DDx.

Green Arrow:
• Kimmilstiel-Wilson Nodule

 

Orange Arrow:
• Hyaline Arteriolosclerosis - VERY common in diabetics

 

To Differentiate Diabetic Nodular Glomerulosclerosis and Light Chain Disease you must do Immunofluorscence

4

What tubular findings would you expect to see in Diabetic Nephropathy?

DIALATED tubules with HYALINE deposits inside

5

What happened to this kidney?

Transplant Rejection

6

Whis is shown here?
• what if it immunofluorusces? What if it doesn't?

IF positive:
• Light Chain Disease

 

IF negative

• Diabetic Nephropathy