What is the most important stage of Diabetic Nephropathy to be able to identify on Histology?
• how is it identified?
Most Important Stage - STAGE III:
• NODULAR glomerulosclerosis => KIMMELSTEIL-WILSON NODULES
***Note: in stage IV the glomeruli become so sclerotic that you can barely make out the basement membrane***
What disease resembles Diabetic Nephropathy on histology?
• how do you differentiate these diseases?
Diabetic Nephropathy and Light Chain Disease resemble each other on Histology with Nodular Glomerulosclerosis
• IMMUNOFLUROSCENCE helps to differentiate between these two things
What is shown here?
• what is the green arrow pointing to?
• what is the orange arrow pointing to?
• Kimmilstiel-Wilson Nodule
• Hyaline Arteriolosclerosis - VERY common in diabetics
To Differentiate Diabetic Nodular Glomerulosclerosis and Light Chain Disease you must do Immunofluorscence
What tubular findings would you expect to see in Diabetic Nephropathy?
DIALATED tubules with HYALINE deposits inside
What happened to this kidney?
Whis is shown here?
• what if it immunofluorusces? What if it doesn't?
• Light Chain Disease
• Diabetic Nephropathy