Flashcards in Diebel Review Sheet Deck (24)
Function of IL-3:
-Growth factor for hematopoietic cells. Important for the proliferation of myeloid progenitor cells.
Function of IL-10:
Anti-inflammatory, blocks the generation of Th1 CD4+ T cells.
Function of IL-12:
Important factor in inducing the production of Th1 CD4+ T cells. Induced IFNgamma production by Th1 CD4+ T cells and NK cells. Enhances NK cell and CD8+ cytotoxic T cell activity.
Function of IL-8:
Chemokine that functions primarily as a chemoattractant and activator of neutrophils
Function of IL-2:
Stimulates proliferation and differentiation of mature T and B cells. (MATURE)
Function of IL-7:
Growth factor for T and B cell progenitors (IMMATURE)
Function of IL-1:
Causes fever and acute inflammation. Activates endothelim to express adhesion molecules.
Function fo IL-4:
Promotes naive CD4+ T cell differentiation to Th2 cells. Induces B cell class switching to IgE.
Function of IL-6:
Causes fever and stimulates production of acute-phase proteins
Function of IL-5:
Induces eosinophil formation and differentiation. Enhances B cell class switching to IgA.
T cells can make interleukins IL1-IL-8, IL-10, IL-12 except. . .
IL-1 and IL-7
Which HLAs display protein produced endogenously?
HLA-A, HLA-B, HLA-C, HLA-E
Which HLAs display protein produced exogenously?
HLA-DO, HLA-DM, HLA-DR, HLA-DQ, HLA-DP
Which HLAs regulate the display of protein fragments within MHC II molecules? How?
HLA-DM catalyzes the exchange of antigenic peptide for the CLIP. HLA-DO regulates HLA-DM
What is CD3?
Signaling chains of TCR
What is CD79a/CD79b?
Signaling chains of BCR
What is CD19?
Part of the B cell co-receptor with CD21 and CD81. Critical for regulating B cell development, activation and differentiation.
What is CD8?
Co-receptor for MHC I -restricted T cell activation
What is CD44?
Involved in lymphocyte activation and homing to lymphoid tissues. Important marker of early T cell development in the thymus. --> If you lack this, you'll have a hard time making it to the thymus
What is CD25?
IL-2 receptor protein. By itself it is just the alpha-chain (low affinity) receptor. When complexed with beta and gamma chains it become a high affinity receptor.
What is CD117?
Stem-cell factor receptor. Important for the development of hematopoietic progenitors.
What is CD4?
Co-receptor for MHC II-restricted T cell activation
What is CD40?
Provides essential co-stimulatory signals for B cell activation, proliferation, differentiation and isotope switching. Stimulates cytokine production by macrophages and dendritic cells. Promotes licensing by dendritic cells