Diebel Review Sheet Flashcards Preview

IHO Week 4 > Diebel Review Sheet > Flashcards

Flashcards in Diebel Review Sheet Deck (24)
1

Function of IL-3:

-Growth factor for hematopoietic cells. Important for the proliferation of myeloid progenitor cells.

2

Function of IL-10:

Anti-inflammatory, blocks the generation of Th1 CD4+ T cells.

3

Function of IL-12:

Important factor in inducing the production of Th1 CD4+ T cells. Induced IFNgamma production by Th1 CD4+ T cells and NK cells. Enhances NK cell and CD8+ cytotoxic T cell activity.

4

Function of IL-8:

Chemokine that functions primarily as a chemoattractant and activator of neutrophils

5

Function of IL-2:

Stimulates proliferation and differentiation of mature T and B cells. (MATURE)

6

Function of IL-7:

Growth factor for T and B cell progenitors (IMMATURE)

7

Function of IL-1:

Causes fever and acute inflammation. Activates endothelim to express adhesion molecules.

8

Function fo IL-4:

Promotes naive CD4+ T cell differentiation to Th2 cells. Induces B cell class switching to IgE.

9

Function of IL-6:

Causes fever and stimulates production of acute-phase proteins

10

Function of IL-5:

Induces eosinophil formation and differentiation. Enhances B cell class switching to IgA.

11

T cells can make interleukins IL1-IL-8, IL-10, IL-12 except. . .

IL-1 and IL-7

12

Which HLAs display protein produced endogenously?

HLA-A, HLA-B, HLA-C, HLA-E

13

Which HLAs display protein produced exogenously?

HLA-DO, HLA-DM, HLA-DR, HLA-DQ, HLA-DP

14

Which HLAs regulate the display of protein fragments within MHC II molecules? How?

HLA-DM catalyzes the exchange of antigenic peptide for the CLIP. HLA-DO regulates HLA-DM

15

What is CD3?

Signaling chains of TCR

16

What is CD79a/CD79b?

Signaling chains of BCR

17

What is CD19?

Part of the B cell co-receptor with CD21 and CD81. Critical for regulating B cell development, activation and differentiation.

18

What is CD8?

Co-receptor for MHC I -restricted T cell activation

19

What is CD44?

Involved in lymphocyte activation and homing to lymphoid tissues. Important marker of early T cell development in the thymus. --> If you lack this, you'll have a hard time making it to the thymus

20

What is CD25?

IL-2 receptor protein. By itself it is just the alpha-chain (low affinity) receptor. When complexed with beta and gamma chains it become a high affinity receptor.

21

What is CD117?

c-kit
Stem-cell factor receptor. Important for the development of hematopoietic progenitors.

22

What is CD4?

Co-receptor for MHC II-restricted T cell activation

23

What is CD40?

Provides essential co-stimulatory signals for B cell activation, proliferation, differentiation and isotope switching. Stimulates cytokine production by macrophages and dendritic cells. Promotes licensing by dendritic cells

24

What is CD80/CD86?

Binds CD28 and is important for co-stimulation of naive T cell activation. Binds CTLA-4 and inhibits T cell activation.