Dimenhydrinate (Gravol, Dramamine) Flashcards Preview

PCP Drug Monographs > Dimenhydrinate (Gravol, Dramamine) > Flashcards

Flashcards in Dimenhydrinate (Gravol, Dramamine) Deck (15)
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1

Dimenhydrinate (Gravol, Dramamine): Classification

1. Anti-emetic

2. Antihistamine

3. Anticholinergic

4. Anti-vertigo

2

Dimenhydrinate (Gravol, Dramamine): Mechanism

1. Inhibits vestibular (labyrinth) stimulation from motion

2. Inhibits cholinergic stimulation in vestibular and reticular systems, which may cause nausea and vomiting

3

Dimenhydrinate (Gravol, Dramamine): Indications

1. Prevention or control of nausea caused by administration of narcotics and/or motion sickness

2. Also has a mild sedative effect for patients about to be moved

4

Dimenhydrinate (Gravol, Dramamine): Contraindications

1. Known sensitivity to Dimenhydrinate,
Diphenhydramine or caffeine derivatives

5

Dimenhydrinate (Gravol, Dramamine): Caution in patients with

1. Glaucoma / Increased intraocular pressure

2. Asthma / COPD

3. Cardiovascular disease (ischemic heart disease and hypertension)

4. Prostatic hyperplasia and urinary obstruction

5. Elderly due to anticholinergic effect

6. Caution in pregnant women (risks/benefits)

6

Dimenhydrinate (Gravol, Dramamine): Dose

1. 25 to 50 mg

2. 12.5 mg in the frail elderly patient

7

Dimenhydrinate (Gravol, Dramamine): Route and Methods of Administration

1. IM given as a direct injection

2. IV diluted with D5W or normal saline

3. Given over 1 minute (25 mg/min maximum)

8

Dimenhydrinate (Gravol, Dramamine): Onset, Duration

1. Almost immediate with IV injection, 3 to 6 hours

9

Dimenhydrinate (Gravol, Dramamine): Elimination

1. Metabolized in the liver, excreted in urine

10

Dimenhydrinate (Gravol, Dramamine): Side Effects - CNS

1. Drowsiness

2. Ataxia (overdose)

3. Disorientation (overdose)

4. Excitement

5. Dizziness

6. Nausea

7. Lassitude (Lack of energy)

11

Dimenhydrinate (Gravol, Dramamine): Side Effects - CVS

1. Hypotension

2. Palpitations

3. Bradycardia/tachycardia

12

Dimenhydrinate (Gravol, Dramamine): Side Effects - GI

1. Dry mouth

13

Dimenhydrinate (Gravol, Dramamine): Side Effects - Respiratory

1. Thickening of bronchial secretions

2. Dry throat

14

Dimenhydrinate (Gravol, Dramamine): Side Effects - GU

1. Dysuria

15

Dimenhydrinate (Gravol, Dramamine): Special Considerations

1. Most side effects are dose-related

2. Discontinue if exaggerated side effects occur