Salbutamol (Ventolin) Flashcards Preview

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Flashcards in Salbutamol (Ventolin) Deck (11)
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1

Salbutamol (Ventolin): Classification

1. Bronchodilator

2. Sympathomimetic

2

Salbutamol (Ventolin): Pharmacodynamic

1. Selective B2 stimulation - bronchodilator and some degree of vasodilation

2. Some B1 effect - especially with repeated doses

3. Little or no A stimulation

3

Salbutamol (Ventolin): Pharmacokinetics

1. Nebulized
- Onset: 5 minutes
- Peak: < 1.5 to 2 hours
- Half-life: 3.8 hours
- Duration: 3 to 8 hours

4

Salbutamol (Ventolin): Indications

1. Bronchospasm associated with asthma, bronchitis or emphysema

2. Bronchospasm & wheezing secondary to other causes

3. May be used in cardiac asthma - with caution

5

Salbutamol (Ventolin): Contraindications

1. Hypersensitivity

2. Hemodynamically significant tachyarrythmias

6

Salbutamol (Ventolin): Precautions

1. Coronary disease (Increase MVO2)

2. COPD pts with degenerative heart disease

3. Diabetes (Decrease effectiveness of insulin)

7

Salbutamol (Ventolin): Adverse Effects

1. Restlessness, apprehension, fear, weakness, vertigo

2. N/V

3. Tachycardia, dysrythmias

4. Paradoxical worsening of respiratory distress, pulmonary edema

5. Sweating, pallor, flushing

8

Salbutamol (Ventolin): Toxicity

1. Discontinue if repeated doses result in signs of Salbutamol toxicity - i.e. if HR > 150 (>200 in pediatric pt), severe tremor, ventricular dysrythmias develop

9

Salbutamol (Ventolin): Dosage

1. 5 mg in 5 ml NS or H2O nebulized (with O2 at 6-8 L/min) - repeat doses back to back pm - watch for signs of toxicity

10

Salbutamol (Ventolin): Pediatric

1. 0.1 mg/kg nebulized in 2-5 cc NS

11

Salbutamol (Ventolin): Special Notes

1. Also a common prescription drug - usual dose MDI is 100 ug inhaled

2. B2 selectivity is lost with high dose

3. 10 mg of Salbutamol may lower serum potassium by as much as 1-1.5 mEq/L (normal is 3.5-5.0 mEq/L) and is sometimes ordered in the setting of hyperkalemia