Flashcards in Salbutamol (Ventolin) Deck (11)
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1
Salbutamol (Ventolin): Classification
1. Bronchodilator
2. Sympathomimetic
2
Salbutamol (Ventolin): Pharmacodynamic
1. Selective B2 stimulation - bronchodilator and some degree of vasodilation
2. Some B1 effect - especially with repeated doses
3. Little or no A stimulation
3
Salbutamol (Ventolin): Pharmacokinetics
1. Nebulized
- Onset: 5 minutes
- Peak: < 1.5 to 2 hours
- Half-life: 3.8 hours
- Duration: 3 to 8 hours
4
Salbutamol (Ventolin): Indications
1. Bronchospasm associated with asthma, bronchitis or emphysema
2. Bronchospasm & wheezing secondary to other causes
3. May be used in cardiac asthma - with caution
5
Salbutamol (Ventolin): Contraindications
1. Hypersensitivity
2. Hemodynamically significant tachyarrythmias
6
Salbutamol (Ventolin): Precautions
1. Coronary disease (Increase MVO2)
2. COPD pts with degenerative heart disease
3. Diabetes (Decrease effectiveness of insulin)
7
Salbutamol (Ventolin): Adverse Effects
1. Restlessness, apprehension, fear, weakness, vertigo
2. N/V
3. Tachycardia, dysrythmias
4. Paradoxical worsening of respiratory distress, pulmonary edema
5. Sweating, pallor, flushing
8
Salbutamol (Ventolin): Toxicity
1. Discontinue if repeated doses result in signs of Salbutamol toxicity - i.e. if HR > 150 (>200 in pediatric pt), severe tremor, ventricular dysrythmias develop
9
Salbutamol (Ventolin): Dosage
1. 5 mg in 5 ml NS or H2O nebulized (with O2 at 6-8 L/min) - repeat doses back to back pm - watch for signs of toxicity
10
Salbutamol (Ventolin): Pediatric
1. 0.1 mg/kg nebulized in 2-5 cc NS
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