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Reproductive > Disease Of Ovaries > Flashcards

Disease Of Ovaries Flashcards

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1
Q

Disease of the ovaries

A

Follicular cysts

Tumors

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2
Q

Follicular cysts single or multiple ?

A

Both

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3
Q

Single cysts presentation

A

Large and associated with amenorrhea

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4
Q

Multiple cysts presentation

A

Smal and associated with endometrial hyperplasia

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5
Q

Type of follicles that lead to follicular cysts

A

Graffian follicle

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6
Q

Cells that line follicular cysts

A

Granulosa cells

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7
Q

Theca lutein cysts surrounded by

A

Luteinised granulosa cells

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8
Q

Pcos type of cysts

A

Bilateral multiple small cysts

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9
Q

Stein leventhal syndrome see in PCOS characteristics

A

Obesity
Hirsutism
Oligomenorrhea

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10
Q

What are chocolate cyst

A

Ovarian endometriosis cysts

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11
Q

Working classification of ovarian tumors

A 
Epithelial tumors 
Sex cord/ stromal tumors 
Germ cell tumors
Others 
Secondary metastatic tumors
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12
Q

2 types of epithelial tumors of ovary

A

Mature mullerian tissue

Analogous tumors

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13
Q

Epithelial tumors of Mature mullerian tissues types

A

Tubal epithelium
Endocervical epithelium
Endometrial epithelium
Transitional epithelium

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14
Q

Analogous tumors types

A

Serous
Mucinous
Endometriod
Brenners

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15
Q

3 types of tumors

A

Benign
Border line
Malignant

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16
Q

Benign tumors characteristics

A

Acini lined by single cell layer

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17
Q

Borderline tumors characteristics

A

Epithelium heaped up
Moderate nuclear atypia and mitoses
No stromal invasion

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18
Q

Malignant tumor characteristics

A

Solid epithelium
Moderate to severe atypia
Stromal invasion

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19
Q

Percentage of surface epithelial tumor in ovarian tumor

A

65-70%

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20
Q

Percentage of surface epithelial tumor of malignant tumor

A

90%

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21
Q

Age group surface epithelial tumor

A

More than 20yo

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22
Q

Ovarian ca concerns developed or developing societies

A

Developed

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23
Q

H what offers protection against surface epithelial tumors

A

OCP

Pregnancy

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24
Q

Risk factor

A

Talc to vulva
Trauma to surface epithelium
Family history (5x more sisters and mothers)

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25
Percentage of hereditary ovaria ca
5%
26
Mutation leading to ovarian ca
P53 pt mutation | If erbB-2 (her-2/neu ) on top , poor prognosis
27
Gynecological malignancy with the most death
Ovarian carcinoma
28
Form of spread of ovarian tumor
predominantly intra-abdominal
29
Ciara marker of ovarian cancer
CA125
30
Serous cystadenoma ovarian tumor percentage
25
31
Morphology Serous cystadenoma
Cuboidal lining epithelium Few Intracystic papillary projection Watery fluid
32
Is malignant transformation common in Serous cystadenoma
Yes
33
Commonest malignant tumor of the ovary
Serous cystadenocarcinoma
34
Percentage of Serous cystadenocarcinoma out of Malignant tumors of ovary
60
35
Morphology of Serous cystadenocarcinoma
Exuberant papillomatosis Groves over surface of ovary which obliterate ovarian structure
36
D percentage mucinous cystadenoma
20% of all ovarian tumors
37
Morphology of mucinous cystadenoma
Multilocular pattern Tall columnar epithelium Gelatinous secretion
38
Type of tumor that can rupture and cause pseudomyxoma peritonei due to mucus secreting epithelium on the peritoneum
mucinous cystadenoma
39
mucinous cystadenocarcinoma % in all carcinoma of ovary
20
40
Morphology of mucinous cystadenocarcinoma
Florid papillary pattern in malignant areas
41
Percentage brenners tumor in ovarian tumor
2%
42
Brenners tumor morphology
Fibroblastic stroma Island of transitional epithelium Mucinous meta0lasia Stromal calcification and cysts
43
What is Endometrioid carcinoma
Solid or semisolid tumor | Mostly arising from surface epithelium of millenarian metaplasia along endometrial lines
44
Is there a benign counterpart to Endometrioid carcinoma
No
45
Two groups of sex cord and stromal tumor
Estrogen producing | Androgen producing
46
Estrogen producing tumor
Granulosa cell tumor | Thecomas or fibromas
47
Androgen producing cell
Sertoli Leydig cell tumors Hilus cell tumor Lipid cell tumor
48
Type of cll in Granulosa cell tumor
Cell resembling Granulosa cells
49
Percentage of Granulosa cell tumor
2% of ovarian tumor
50
Morphology of Granulosa cell tumor
``` Micro follicle (call exner bodies) Coffee beans cells ```
51
Hormone excessively produced in Granulosa cell tumor
Estrogen
52
What are Thecomas
Tumor of ovarian mesenchyme
53
Morphology Thecomas
Unilateral Firm solid
54
Consequences of estrogen production
Precocious puberty Endometrial hyperplasia Enlargement of breast Post menopausal bleeding
55
Main association to fibromas
Meigs syndrome wirh peritoneal and pleural effusion
56
Tumor that typifies virilising tumor group
Sertoli-Leydig cell tumor
57
Sertoli-Leydig cell tumor macro morphology
Small Yellow in ovary
58
Sertoli-Leydig cell tumor micro morphology
Tubule line day Sertoli cell | Leydig cell in stroma like testes
59
Androgen release consequences
``` Atrophy of testes External genitalia atrophy Voice deepening Facial and body hair growth Clitoris enlargement ```
60
Different ways germ cell tumor can différente
Primitive cell - dysgerminoma Embryonic differentiation- Teratoma Extra embryonic differentiation - yolk sac tumor , choriocarcinoma
61
What are dysgerminoma
Malignant | Solid tumor
62
dysgerminoma morpho
Large round cell with large nuclei resembling germ cells Alveoli pattern Fine connective tissue
63
Teratomas type
Mature and immature | Cystic or solid
64
Cystic Teratoma
``` Common tumor of ovary All ages Unilocular Eminence of one part with hair stratified squamous epithelium which can become malignant ```
65
Solid teratoma characteristics
Solid Unilateral Large rare
66
What is monoplyetic Teratoa
One type of tissue Stroma ovarii is thyroid tissue Carcinoid tumor seen in ovary
67
Highly malignant tumor of women under 30yo
Yolk sac tumor
68
Histology of yolk sac tumor
Resemble mesenchyme of primitive yolk sac
69
Second most common malignant germ cell tumor
Yolk sac tumor
70
Morphology of yolk sac tumor
Large extensive necrosis and hemorrhage Reticular honeycombed structure of communicating species lined by primitive cells Schiller duval bodies
71
Regarde are Schiller duval bodies
Papillae that protrudes into space lined by tumor cells and contai; fibrovascular core
72
Protein secreted by yolk sac tumor
A-fetoprotein seen I pin eosinophilic droplets
73
Prognosis for yolk sac tumor
Good nowadays due to chemotherapy | Exceed 80% 5ysr
74
Staging of ovarian cancer
75
What is choriocarcinoma
Secretes hcg highly metastatic | Similar to gestational choriocarcinoma
76
Secondary tumor of ovaries which is Adenocarcinoma from stomach or large intestine
Krukenberg tumor
77
Characteristics of krukenberg tumor
Mucous secretion Signet ring cell Bilateral
78
Lymphomas of the ovaries, primary or secondary
Both
79
Burkitt lymphoma of ovaries primary or secondary
Primary

Reproductive (14 decks)

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