Disorder Drug Targets

Question 1

Psychoses

Answer 1

Path: + limbic DA –> positive symptoms, - PFC DA –> negative symptoms
Pharm: block D2 and 5HT2A receptors

Question 2

Depression

Answer 2

Path: - 5HT-NE
Pharm: + synaptic 5HT, NE (and DA)

Question 3

Mania

Answer 3

Path: + NE-DA activity
Pharm: Modulate NT activity, block VSSC-VSCC

Question 4

Anxiety

Answer 4

Path: - 5HT-GABA or + NE
Pharm: Enhance 5HT and GABA activity

Question 5

ADHD

Answer 5

Path: Deficient DA-NE
Pharm: + DA (D1)-NE (a2) activity

Question 6

Insomnia

Answer 6

Path: deficient inhibitory GABA
Pharm: + GABA activity, - ACh and histamine activity

Question 7

General Anesthesia

Answer 7

Path: No path!
Pharm: + GABAa activity, - NMDA-R fxn

Question 8

Seizure

Answer 8

Path: abnormal VSSC-VSCC, - GABA and + GLU activity
Pharm: + GABA activity, Block VSSC, VSCC