Disorders of peripheral nerves Flashcards Preview

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Flashcards in Disorders of peripheral nerves Deck (17):
1

Footdrop

Inability to raise the front part of the foot due to weakness/paralysis of common perioneal nerve

• Common perioneal nerve is involved in the dorsi flexion of the ankle runs along front of the foot

2

Carpel tunnel

• compression of median nerve at the wrist
•Any process which causes narrowing of the carpal tunnel

3

Diabetic neuropathy

• Family of nerve disorders cause by diabetes
• People with diabetes develop nerve damage throughout the body due to high blood glucose
• Wasting, numbness and tingling
• Peripheral neuropathy is most commone

4

Carcot Marie tooth disease

Group of heriditary disorders of the peripheral nervous system
• Autosomal dominant
• Get worse over time
• Affect both sensory and motor neuronal cells

5

Guillian Barre

1. rare but serious autoimmune disorder in which immune system attacks peripheral nerves
• Rapidly progressing acute polyneuropathy
• Leads to weakness, numbing, and eventually paralysis

6

Multifocal motor neuropathies

• acquired autoimmune condition that affects the body's motor nerves
• No pain but twitching and cramping

7

Autonomic neuropathy

• non sensory and non motor functions affected by autonomic nerves
causes changes in digestion, bowel and bladder function, sexual response

8

Focal neuropathy

sudden weakness in one nerve or group of nerves causing muscle weakness or pain

9

Pathophys of charcot-marie-tooth disease

Defective protein in myelin sheath or axon
( may cause myelin sheath degeneration or directly affects axons preventing electrical signal transmission )

• Slows down electrical impulses travelling along the neuron
• Signals fail to reach target tissues in both sensory and motor neurons
• Motor neurons are affected it leads to muscle atrophy of the muscle it supplies

10

Symptoms of CMT

Symptoms
1. Motor neuronal
- both motor and sensory symptoms
-foot and leg weakness - footdrop and high step gait

2. Sensory
Tinging and burning sensation in hands and feet

11

Polyneuropathy

degeneration of peripheral nerves that spread away from the centre

12

Causes of guillian barre

• Post infection with certain organisms such as campylobacter jejuni/HIV
• cell mediated auto immune response is triggered against myelin/component of peripheral nerve

13

Causes of foot drop

• Muscle weakness - muscular dystrophy
•Peripheral nerve disease/ neuropathy- charcot-marie-tooth/diabetic neuropathy
• Compression of common perioneal nerve

14

Carpal tunnel clinical features

• altered sensation in the median nerve distribution
• Weakness of thumb abduction
• Wasting of thenar eminence

15

Mononeuropathy

disorder of a single peripheral nerve resulting from trauma or compression the nerve

16

Mononeuritis multiplex

damage to two or more indivisual nerves

17

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