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Flashcards in Disorders of neural transmission Deck (10):
1

Myasthenia Gravis

• Acquired autoimmune condition where antibodies attack post synaptic acetylcholeine receptors

• Associated with hyperplasia of thymus gland

• Myasthenic crisis - decreased firing of muscles which control breathing

2

Lambert eaton myasthenic syndrome

• Antibodies against calcoim channels of presynaptic motor nerves
• Myasthenia like illness
• Affects lower limbs

3

Duchenne muscular dystrophy

• A type of muscular dystrophy
• X linked recessive disorder affecting males alone and present in early life
• Mutation in gene coding for dystrophin
• Muscle weakness and wasting of muscles

4

Myasthenia gravis clinical features

• Fatigueable muscle weakness
• Ptosis
• Fatigue of facial and bulbar muscles causing dysphagia and dyarthia

5

Muscular dystrophies

inherited disorders characteries by progressive muscle weakness and wasting
• Duchenne muscular dystrophy is the most common

6

Clostridiol toxins

• Produced by C diff bacteria
• Damage intestinal mucosa and cause symptoms of Cdiff infection

7

Hypokalemic periodic paralysis

• Autosomal dominant trait
• Mutation in voltage gated calcium channel
• Muscle weakness or paralysis occurs
• Reduced levels of potassium

8

Hyperkalemic periodic paralysis

• AD
• Mutation in voltage gated sodium channel gene
• Potassium level elevation
• Weakness and involuntary muscle contraction (myotonia)

9

Limbic encephalitis

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10

Neuromyolonia

Acquired neuromyotonia is an inflammatory disorder characterized by abnormal nerve impulses from the peripheral nerves that result in continuous muscle fiber activity. Affected individuals often experience progressive muscle stiffness and cramping especially in the hands and feet
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