Disorders of the neuromuscular function

Question 1

Myasthenia gravis may present as a paraneoplastic syndrome associated with:

Answer 1

Thymoma (may also have thymic hyperplasia)

Question 2

What is the best initial test for myasthenia gravis?

Answer 2

Anti-ACh receptor antibody test

Question 3

_______is an acetylcholinesterase inhibitor that is used as long-acting treatment for myasthenia gravis

Answer 3

Pyridostigmine

Question 4

Which neuromuscular junction pathology is characterized by fluctuating muscle weakness?

Answer 4

Myasthenia gravis

Question 5

Myasthenia gravis presents with muscle weakness that ______with muscle use

Answer 5

worsens

Question 6

Which neuromuscular junction pathology is characterized by diminished or absent deep tendon reflexes?

Answer 6

Lambert-Eaton myasthenic syndrome

Question 7

Active muscle contraction or repeated muscle tapping increases reflex activity in a patient. Which test is most likely to confirm the diagnosis?

Answer 7

Autoantibodies against voltage-gated calcium channels

Question 8

Lambert-Eaton myasthenic syndrome (LEMS) is a paraneoplastic syndrome associated with

Answer 8

small cell lung cancer (SCLC)

Question 9

Unlike MG, Patients with Lambert-Eaton myasthenic syndrome (LEMS) present with:

Answer 9

autonomic symptoms (dry mouth, constipation, impotence)

Question 10

Is pyridostigmine effective in acute myasthenic crisis?

Answer 10

No

Question 11

Inital intervention in patients with myasthenic crisis and signs of impending respiratory failure (e.g., pallor, anxiety, tachycardia, tachypnea, cyanosis)

Answer 11

Early endotracheal intubation

Question 12

Treatment of acute exacerbation/myasthenia crisis:

Answer 12

Plasmapheresis or IVIG +- steroids