Diuretics Flashcards
Common indications of diuretics
*all treat volume overload states by increasing urine volume *
HF, CKD, renal failure, idiopathic edema, HTN, diabetes insipidus, glaucoma, nephrolilithis, hypercalcemia
What are the two major board diuretic categories?
Natriuretics
- increase urine volume by excretion of Na+
- includes: spironolactone, furosemide, and carbonic anhydrase inhibitors
Aquaretics
- increase urine volume by excretion of solute-free water (just water)
- includes: mannitol, desmopressin, conivaptan
Where do diuretics act?
Inside the tubule. MOST diuretics get absorbed in the PCT to actually start its effects
Common adverse responses to diuretics
Rapid loss of ECF by reducing plasma volume
Low blood volume and hyponatremia
Metabolic alkalosis
- too much reduction in ECF without concomitant reduction of bicarbonate
Hypomagnesemia, hyperuricemia, hyperlipidemia
Otoxcity and drug allergies
Where does carbonic anhydrase inhibitors work?
The PCT
- classic prototype is acetazolamide
Indicated most for edema and glaucoma
How does sodium reabsorption work in PCT
Basolateral Na/K+ ATPase pumps establish Na+ concentration gradient favoring sodium moving INTO PCT from urine (reabsorption)
-however, to move into interstital fluid, requires carbonic anhydrase enzymes to produce H+/HCO3- ions intracellularly from H20/CO2 extracellularly
Secondary active transporters use this sodium gradient to reabsorb proteins, glucose and other ions as well as sodium itself.
What is the physiological responses to carbonic anhydrase inhibtors
Increases delivery of solutes to the macula densa which induces tubuloglomerular feedback
- increases afferent arteriolar resistance which reduces renal blood flow and GFR
(how it combats diuresis)
What does the ceiling effect and diuretic threshold effects for loop diuretics mean?
Threshold effect = requires a certain dose to actually work and elict an effect
Ceiling effect = after a certain dose (varies amount patients, there can no more benefit and only harm to the patient
because of the ceiling effect, you need to monitor what is the appropriate dose for each patient
What drives the paracellular reabsorption of (Ca2+/Mg2+) cations in the TAL?
ROMK channels (potassium efflux channels in TAL) - establishes a trans-epithelial voltage differential in the lumen which pushes Ca2+/Mg2+ into the TAL/interstital space
Where do thiazaides act on?
DCT
Where do loop diuretics work?
Loops of Henle and TAL
Where do thiazides work?
DCT
How does thiazides sometimes cause hyperglycemia?
Off target effect that binds to ATP-sensative K+ channels on pancreatic B-cells and act as a agonist
- this hyperpolarization of these cells prevents insulin release
Diuretic adaptation and resistance
Kidneys are highly adaptive and will induce a “braking phenomenon” where it essentially adapts tot he diuretic effects to prevent too much excretion or reabsorption
Most common type of diuretic combination therapy
Loop diuretics + thiazides (metrolazone usually)
- used to treat refractory loop diuretic treatment
- blocking’s both TAL and DCT syngeriszes the effects
very high risk of K+ wasting and hypokalemia though
How does desmopressin and vasopressin differ in function?
Desmopressin = acts only on V2R receptors
- much higher antidiruetic effects with minimal vasoconstriction
Vasopressin = ACEIs on V1aR/V1bR and V2R receptors
- has both high antidiuretic and vasoconstriction effects
Difference between central diabetes insipidus and nephrogenic diabetes insipidus
Central diabetes insipidus:
- inadequate production or secretion of ADH by the posterior pituitary
- wide variety of causes
- first line treatment is ALWAYS vasopressin agonist (unless CAD is present)
Nephrogenic diabetes insipidus
- inadequate response of the kidney to ADH (doesnt respond to it)
- almost always hereditary (mutations in V2)
- can also be drug induced or electrolyte toxicity
- first line treatment varies based on MOA of issue (usually thiazides)
How does diabetes insipidus occur in pregnancy
Increasing levels of circulating vasopressinase (which decreases natural vasopressin sensativity)
DONT give direct vasopressin
What is first line therapy in nephrogenic DI
Thiazides diuretics
- works by reducing RBF/GFR and allows for more reabsorption in the proximal tubule
lithium induced nephrogenic diabetes insipidus
Occurs in 1:3 patients using lithium
- occurs due to reduces cAMP production by reducing V2 receptor agonism by lithium using ENaC receptors in the collecting tubule
- Results in less aquaporins in the collecting ducts and more water secretion
- also increases plasma levels of PTH
Treatment = first line is amiloride to block lithium from using ENaC to enter collecting tubules
What vasopressin antagonists can be used for SIADH
Democlocycline And tolvaptan
cant use demeclocycline in patients under 12
What vasopressin antagonists can be used in CHF?
Conivaptan
- binds to V1aR receptors and decreases peripheral vascular resistance/increases cardiac output
Tolvaptan
- adjuvant only for diuretic therapy in CHF patients
used to combat hyponatremia seen in heart failure due to elevated ADH levels
Vasopressin antagonists to use in polycystic kidney disease
Tolvaptan
- blocks V2R receptors and reduces cAMP levels which delays cysts formation
- produces hepatotoxicity however
What is osmotic demyelination syndrome
A acute quick rise in sodium levels after originally being hyponatremic
- the lower the initial hyponatremic, the worse osmotic demyelination syndrome can be
Results in rapid fluctuations of ECF/ICF volumes and causes damage myelin sheaths and causes neurotoxicity symptoms
alcoholism and SIADH both increases the risk significantly
