Diuretics and RAAS antagonists II Flashcards Preview

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Flashcards in Diuretics and RAAS antagonists II Deck (14):
1

Effect of diuretic agents on plasma electrolytes:
Which class reduce K+ (hypokalemia)?
________
Which one increase K+?

1. Loop
2. Thiazide
3. Loop + Thiazide
____________

1. Aldo antag

2

Hypokalemia adverse effects

can result in weakness, paresthesias, cardiac sensitization (predisposition to ectopic pacemakers),

thus use not advisable in patients with arrhythmias, history of myocardial infarction, pre-infarction angina

3

Effect of diuretic agents on plasma electrolytes:
Which class increases Urate?

1. Loop
2. Thiazide
3. Loop + Thiazide

4

Effect of diuretic agents on plasma electrolytes:
Which class reduces Ca2+ ?

Loop

5

Effect of diuretic agents on plasma electrolytes:
Which class reduces Mg2+ ?

Loop

6

Effect of diuretic agents on plasma electrolytes:
Which class increases Ca2+ ?

Thiazide

7

NaCl reabsorption occurs out of which part of the renal tubule?

Distal convoluted tubule

8

Thiazides increase _________ of Ca++ ( NOTE: loop diuretics ______ serum Ca++ levels)

reabsorption
decrease

9

Which drugs can ppt a gout attack?

thiazide diuretics

10

Which drugs are most efficacious in HF? Which drugs are infrequently used in HF?

Loop diuretics
Thiazides

11

True/False: Triamterene and Amiloride block pro-fibrotic actions of aldosterone

False: no utility in HF

12

Adverse rxn of K+ sparing diuretics

Hyperkalemia--> EKG changes, conduction abnormalities, arrhythmias.

13

Types of drugs that are anti-remodeling with Decreased:
Hypertrophy
Fibrosis
Apoptosis

1. ACE INHIBITORS / ANGIOTENSIN RECEPTOR BLOCKERS

2. BETA BLOCKERS

3. ALDOSTERONE RECEPTOR BLOCKADE

- All 3 REDUCE MORBIDITY AND IMPROVE SURVIVAL

14

ACEI potential side effects

+ bradykinin --> chronic dry cough

- hypotension
- plasma K+ increase
- contraindicated in pregnancy (just like ARBs)