Flashcards in Diuretics and RAAS antagonists of HF Deck (40)
Diuretics act on ___ surface
___ interact with membrane transport proteins
Thiazides, Furosemides, Triamterene
___ interact with enzyme and ___ interact with hormone receptors
___ osmotic effect
___ is a carbonic anhydrase inhibitor
CA inhibitors causes ____ in ____ (what and where)
decrease NaHCO3 reabsorption
Loop of henle water removal in ___ limb and Na ___ in ___limb
NaCl Reabsorption in accending
Na reabsorpted in ascending limb via ______?
NKCC2 (NaK2Cl co transporter
Loop diuretics do what?
Mg/Ca excretion (K intracell high, difuse back to lumen (K channel) drives Mg/Ca reabsorption)
Uses of Loop Diuretics
CHF (volume overload)
Refractory edema (+thiazide, aldosterone antagonists)
Acute Pul Edema
HF have ___ diuretic response due to:?
Decrease drug delivery to kidney, decrease RBF, hypoperfusion activatoin of RAS/SNS
Loop diuretic adverse effects
hypokalemic metabolic alkalosis (increase K/H secretion)
Hypokalemia predisposes pt to ___?
Loop diuretics includes?
Furosemide (most common)
Bumetanide, torsemide (higher F and longer t1/2)
DCT is _____ to H2O
Na is reabsorpted in DCT via ___?
NCC (NaCl co transporter)
Ca reabsorption occurs via ___?
NCX in DCT is regulated by
PTH (Parathyroid hormone)
Thiazides inhibits ___
NCC (increase NaCl excretion)
Thiazides _______ Ca
increase reabsorption of Ca
(low Na intracellular, activates NCX, decrease Ca intracell, Ca reasborbed from urine)
Thiazides drugs include ___?
hydrochlorothiazide (prototype 2x/day)
chlorthalidone/metolazone - longer duration
Thiazide adverse efects
hyperaldosteronism (volume decrease)
Hyperuricemia (precipitate gout attack)
hyperlipidemia (HTN risks)
Allergic - sulfonamide
Thiazide acts in ___
Aldosterone acts on __
K excretion is ____ to Na ______ in CT
Aldosterone acts on CT by ____?
gene transcription - increase number/activity of Na/K-atpase
Trimaterne, amiloride diuretics acts by ___ at __
direct Na Channel block
(less Na reabsorb = less K excreted
Apironolactone/eplerenone act by ____ at __
competitive antagonist at aldosterone receptor
- decrease Na reabsorption, decrease K excretion
Uses of potassium sparing diuretics
CHF - aldosterone antag (also at heart)
PCOS Hirustism - block androgens