Division and Chromosomal Heredity Flashcards

(47 cards)

1
Q

what are the different morphological types of chromosomes

A

metacentric-equal length arms
submetacentric-p arm shorter
acrocentric-no p arm

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2
Q

differences between homologous chromosomes and sister chromatids

A

Homologous-similar NOT IDENTICAL. carry different versions of the same gene

Sister-genetically identical

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3
Q

how many pairs of chromosomes are found in a typical human somatic cell

A

23 pairs(46 chromosomes)

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4
Q

prime difference between mitosis and meiosis

A

mitosis produces diploid cells 2 genetically identical (diploid) daughter cells

meiosis produces 4 genetically different haploid cells for sexual reproduction

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5
Q

T/F between interphase and mitosis cells can enter G0 stage in which they are quiescent

A

True

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6
Q

T/F DNA synthesis occurs during S phase of interphase stage

A

TRUE. DNA is replicated

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7
Q

T/F the interphase is characterized by absence of visible chromosomes

A

TRUE

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8
Q

T/F transitions from one interphase stage to the other are controlled by cell cycle checkpoints

A

TRUE

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9
Q

what is the role of chromosomes in cell division

A

allow DNA to be replicated accurately

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10
Q

what is a karyotype? when is the best time to obtain one during mitosis?

A

image of a complete set of chromosomes in an organism taken during metaphase

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11
Q

stages of mitosis and brief description

A

Prophase-nuclear membrane breakdown
Prometaphase- chromosomes begin to condense, formation of spindles
Metaphase-full chromosome condensation, spindles attach
Anaphase-separation of sister Chromatids
Telophase-formation of 2 new nuclear membranes

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12
Q

if 2n=6 how many DNA molecules and chromosomes are there for each cell in:
G1
G2
mitotic metaphase
mitotic anaphase

A

G1: 6 chromosomes, 6 DNA molecules

G2: 6 chromosomes, 12 DNA molecules

mitotic metaphase: 6 chromosomes, 12 DNA molecules

mitotic anaphase: 12 chromosomes, 12 DNA molecules

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13
Q

what is the effect of colchicine on the cell cycle

A

causes damage to the spindle and arrests mitosis(at metaphase)

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14
Q

T/F at completion of metaphase, the chromosomes align in metaphase plate with spindles attached to TELOMERES

A

FALSE. They attach at the kinetochore

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15
Q

what is karyokinesis? what phase does it occur

A

formation of 2 new nuclear membranes. occurs during telophase

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16
Q

what is cytokinesis? what phase does it occur

A

formation of 2 new cell membranes, occurs during telophase

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17
Q

stages of meiotic division and brief description

A

prophase I(5 stages)
metaphase I-tetrads orient on metaphase plate
Anaphase I-disjunction (separation of homologs)
Telophase I-much shorter than mitotic phase
Prophase II-telophase II-similar to mitosis

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18
Q

explain monad, dyad, and tetrad, and how many DNA molecules and strands in each

A

Monad-1 molecule, 2 strands
Dyad-2 molecules, 4 strands
tetrad-4 molecules, 8 strands

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19
Q

what are chiasmata and when do they occur?

A

site of recombination, occurs in prophase I (pachynema)

20
Q

what is crossing over? what is its biological importance?

A

homologs exchange genetic material
leads to genetic variation

21
Q

T/F in spermatogenesis, spermatogonia undergo first meiotic division to produce primary spermatocytes

22
Q

what are recombination hotspots? what is an example?

A

they are short regions all over genome for recombination
-major histocompatibility complex
-pseudoautosomal region in males

23
Q

what are recombination coldspots? what are examples?

A

on centromeres

24
Q

T/F secondary spermatocytes undergo meiosis II to produce haploid spermatids

A

TRUE, however sperm cells become haploid after meiosis I

25
T/F in oogenesis primary oocytes are diploid as well as the secondary oocytes
TRUE, they become haploid after second meiotic division
26
T/F polar bodies are the result of equal cytoplasm division during meiosis I
FALSE. cytoplasm division is unequal
27
what is the dictyate stage?
oogenesis arresting at diplonema during meiosis I
28
unique features of meiosis in female mammals
all mammalian females are mosaics for maternal and paternal X-linked alleles
29
what kind of trait is milk production? in mammals why do only females have milk production?
it is a sex limited trait. hormones in females activate mammary glands
30
sex-limited vs sex influenced
sex-limited: expression of specific phenotype is absolutely limited to one sex sex-influenced: sex influences phenotype, but it is not limited to one sex
31
examples of sex limited traits
breast development beard growth
32
examples of sex influenced traits
pattern baldness
33
what mechanism balances expression levels of genes found on X chromosomes between genders
Barr bodies/dosage compensation
34
what are barr bodies
heterochromic X-chromosome, histones are deacylated, DNA is methylated
35
which group of genes escape X inactivation
PAR X-Y gemetologs
36
which features of X inactivation causes large patches of orange and black color to appear in tortoiseshell cats
random X inactivation
37
what is the role of the XIST mechanism in the X inactivation process
X-inactivation specific transcript, produces large RNA molecule to "paint" the chromosome to be inactive
38
what kind of gene is XIST
non coding RNA
39
what is the importance of the SRY gene
produces transcription factor needed for male-specific gene expression
40
2 main sex chromosome systems in nature, how do they differ?
X/Y system, based on presence/absence or SRY Z/W system, used in birds and reptiles females are Z/W, and males are ZZ
41
explain drosophila sex determination A:X ratio
sex is determined by ratio of X chromosomes to autosomes(A) females: 1:1 (AA XX) males- 2:1 (AA X)
42
5 stages of Prophase I
leptonema zygonema pachynema diplonema diakinesis
43
leptonema
homologs find each other
44
zygonema
start of homolog pairing
45
pachynema
homolog pairing complete, formation of tetrads, start of crossing over
46
Diplonema
non sister chromatids start to separate
47
diakinesis
nuclear envelope dissolve so cell can enter metaphase