DNA Viruses Flashcards
(29 cards)
What are all the DNA virus families?
1) parvovirus
2) Papovavirus
3) Adenovirus
4) Herpes Virus
5) Poxvirus
6) Hepadnavirus
Which of the DNA viruses are double stranded?
- All except for the parvo virus
What is the main virus in the Parvovirus family?
What are this virus’s disease manifestations?
- B19 - smallest and single stranded
- Erythema infectiosum AKA 5th disease AKA slapped cheek fever
What is the pathogenesis of B16 disorder?
What population is this disease most dangerous in?
- targets erythroid precursors, follows a biphasic course (febrile–>symptomatic)
- Chronic anemia patients are most atrisk for an aplastic crises (depletion of rbc precursors) and pregnant women –>cross the placenta
How is B19 transported?
What is the classical path of “Slapped cheek fever” in children?
- via respiratory and oral secretions and across the placenta
- Initially on the cheeks it spreads to the extremities.
What is the hallmark of B19 disease process in adults?
What does the B19 disease cause in pregnant women?
- Arthralgia and arthritis
- hypoxic damage to the heart, liver, and other tissues leading to edema and hydrops fetalis and possibly still birth
What disease must B19 be differentiated from in pregnant women?
Rubella via IgM specific ELISA
What viruses are associated with Papovaviruses?
- hyman papilloma virus, commmon warts, genital warts, and BK and JC viruses in the immmunocompromised.
What are the associated features of HPV?
What is the pathogenesis of HPV?
- Plantar warts, flat and papillomatous warts, laryngeal papillomas, genital warts, and cervical cancer
- Pathogenesis: enters through breaks in skin (warts) or mucous membranes (genital and oral papillomas)
How is HPV acquired?
What are the common symptoms?
- Direct contact, sexcual contact, birth, chewing
- Common, plantar and flat warts, Laryngeal, Condylomata acuminata (genital warts)
What types of HPV present with condylomata acuminata?
What types of HPV are associated with cervical dysplasia?
- HPV-6 and HPV-11
- HPV-16 and HPV-18 - cauliflower lesion
What are the diagnostic cells during a pap smear present in HPV?
- Koilocytic cells
What patient population do BK and JC viruses occur in?
-Disease manifestions of BK viruses?
- immunocompromised
- Hemorrhagic cystitis in renal and bone marrow transplant patients
What are the manifestions of JC viruses?
- Progressive multifocal leukoencephalopathy, degenerative disease of the brain
What cells do Adenoviridae invade?
How is Adenoviridae spread?
- epithelial cells lining the oropharynx, respiratory, enteric
- human to human transmission in classrooms or military via fecal/oral, fingers, fomites, swimming pools
What are the clinical syndromes of Adenovirus?
What is classic pathogenesis of adenovirus?
- Pharyngitis, acute respiratory tract disease (cervical adenitis), Conjunctivitis (swimming pools)
- pink eye (conjunctivitis) AND soar throat (pharyngitis)
What are the viruses in the poxviruses family?
Whats unique about the size of the poxvirus?
- Orthopox (smallpox) and molluscipox (molluscum contagiosum, org, and monkeypox)
- Largest virus
Where does the smallpox virus spread during first infection, second infection?
first infection: respiratory tract and disseminates via lymphatics–> viremia
second infection: infects all dermal tissues and internal organs
How is smallpox contracted?
Where does viral DNA replicate?
- respiratory route
- in the nucleus
Where does the small pox virus replicate?
What are the differentiating features of small pox and chicken pox?
- in the respiratory system
- In small pox they are in the same stage and in chickenpox they are in different stages. In smallpox there is a higher concentration on the arms, legs, and face while in chickenpox there is a higher concentration on the thorax and abdomen.
What animals do you get monkeypox from?
- from prairie dogs - more benign
What is the most common spread of molluscum contagiosum?
Where are nodules most common?
- Spread by STD, wrestling
- Wart-like nodules on trunk, genitalia, and extremities
What is diagnostic for mollluscum contagiosum?
- cytoplasmic inclusions in epithelial cells
What is the major virus in hepadnaviridae?
What occurs with the viral DNA once in?
- Hepatitis B virus
- RNA gets reversed transcribed
