DOACs Flashcards
cerebral vascular accident (stroke)
stroke that resolves itself within hrs
no damage on MRI
Treatment same as stroke
assoc. w/ increased risk of stroke in future
ischemic stroke
blockage of some type- causes decreased blood flow and tissue damage;
clot, emboli, plaque
hemorrhagic stroke
bleed in the brain tissue
causes increased pressure, swelling, and tissue damage
hypertension (risk factors for stroke)
lesion in brain and white matter damage
damage occurs before increased BP
due to increased O2 free radicals prod. by perivascular macrophages
increase dietary salt (risk factors for stroke)
decreased cerebral blood flow, endothelial dysfunction, cognitive impairment
microbiome (risk factors for stroke)
altered by lifestyle, diet, meds
alteration of biome + aging = increased stroke risk
atrial fibrillation (risk factors fro stroke)
not completely emptying blood sites and no flow so setup for clotting
increased cholesterol (risk factors for stroke)
plaque formation inhibits blood flow so setup for clotting
diabetes (risk factors for stroke)
better outcomes if 80-130mg/dl
tissue damage due to superoxide formation leads to setup for stroke
ketogenic diet (risk factors for stroke)
can cause tissue damage due to fat metabolism and decreased glucose metabolism= setup for stroke `
stroke prevention
antithrombotics
anticoagulants
DOACs
Statins
manage glucose/salt levels
antihypertensive meds
antithrombotics
aspirin & other plt inhibitors
anticoagulants
warfarin
unfractionated heparin
LMWH
warfarin/ coumadin
inhibits factors 2, 7, 9, 10
hard to manage
easy to reverse
regular testing required
unfractionated heparin
through IV
immediate acting, variable response, must be monitored
