quiz 2 review

Question 1

Ellagic acid or kaolin in the APTT reagent provide

Answer 1

maximum contact activation

Question 2

Which of the following are natural controls of fibrinolysis?

Answer 2

alpha 2 antiplasmin
alpha 2 macroglobulin

Question 3

A person who has a Protein S deficiency would tend toward:

Answer 3

clotting

Question 4

Factor XIIa role

Answer 4

activates plasminogen to plasmin

Question 5

Factor VIIIa role

Answer 5

complexes with V, X to activate X to Xa

Question 6

Factor XIIIa role

Answer 6

stabilizes the fibrin clot

Question 7

Factor VIIa role

Answer 7

activates X to Xa

Question 8

Factor IIa role

Answer 8

converts fibrinogen to fibrin monomer

Question 9

A patient who has a Factor IX activity level of <1% has which of the following disorders?

Answer 9

Hemophilia B

Question 10

If an individual has a normal PT, a prolonged APTT, a normal TT, 1:1 with normal plasma for APTT
= correction; 1:1 with saline for APTT = no correction, what is the most likely reason?

Answer 10

Factor XI deficiency

Question 11

Streptokinase and urokinase are:

Answer 11

medications that activate plasminogen

Question 12

Lupus anticoagulant (inhibitor):

Answer 12

may cause a prolonged APTT
is an antibody to phospholipid

Question 13

Protein S:

Answer 13

is a cofactor for Protein C
is vitamin K dependent

Question 14

Causes of an increased thrombin time:

Answer 14

dysfibrinogenemia
heparin in the sample

Question 15

The INR (International Normalized Ratio):

Answer 15

is usually reported with the PT
standardizes testing for different PT reagents
is calculated using the ISI (International Sensitivity Index) of the PT reagent
is especially important for patients being treated with coumadin

Question 16

An abnormally high amount of D-dimer indicates:

Answer 16

increased fibrinolysis
increased clotting

Question 17

PAI (I) - Plasminogen activator inhibitor I:

Answer 17

inhibits fibrinolysis

Question 18

Coagulation proteins are made primarily:

Answer 18

in the liver

Question 19

Protein C and Protein S:

Answer 19

are inhibitors of coagulation
act on Factors Va and VIIIa

Question 20

How does Vitamin K participate in the coagulation process?

Answer 20

it activates Factors II, VII, IX and X by carboxylating them

Question 21

In a patient with disseminated intravascular coagulation (DIC), one can expect:

Answer 21

prolonged PT, APTT, TT
decreased platelet count

Question 22

Which coagulation factors are consumed in the clotting process?

Answer 22

I and II
V and VIII

Question 23

How is Factor XII activated?

Answer 23

by contact with negatively charged surfaces

Question 24

Which factor circulates in combination with Von Willebrand’s factor?

Answer 24

Factor VIII

Question 25

The intrinsic pathway factors are evaluated by the:

Answer 25

APTT

Question 26

Antithrombin has a major role in _____________________, and its effect is potentiated by________________.

Answer 26

clot prevention; heparin

Question 27

Thrombin has an important role in clot formation, but also an important role in preventing clot formation by:

Answer 27

it binds to thrombomodulin and activates Protein C it stimulates the release of tissue plasminogen activator

Question 28

A patient presents with the following test data. Select the choice(s) that would be consistent with the results. PT = 12 sec APTT = 33 sec TT = 16 sec

Answer 28

normal

Question 29

Testing methods for D-dimers:

Answer 29

latex agglutination immunoassay using sandwich technique

Question 30

Which of the following are principles of clot detection used in coagulation instruments?

Answer 30

change in optical density electromechanical

Question 31

Fibrin monomers:

Answer 31

are the product of the action of thrombin on fibrinogen are increased in DIC and liver disease

Question 32

What is the Laurel Rocket electrophoretic technique usually used to detect?

Answer 32

coagulation factor antigenic amount

Question 33

The PIVKA test is used mainly for:

Answer 33

detection of Vitamin K deficiency