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Apex 4 - 2 Pharmacodynamics (5) > Dose Response Curve > Flashcards

Flashcards in Dose Response Curve Deck (36)
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1

On the dose-response curve, the x-axis correlates with:

Study on!!!!!

2

The ----- curve illustrates the relationship between the drug dose and its clinical effects

Dose-response curve

3

The dose-response curve illustrates the relationship between the drug dose and its clinical effects. It tells us about: 

Efficacy

Slope

Potency

4

----- is the dose required to achieve a given clinical effect

 

Potency

5

Potency is the dose required to achieve a given clinical effect. It is represented by the ----- axis

 

X-axis

6

Potency is affected by:

Absorption

Distribution

Metabolism

Elimination

Receptor affinity

7

The ----- represent the dose required to achieve a given effect in 50% of the population

ED50

8

The ----- represent the dose required to achieve a given effect in 90% of the population

ED90

9

The ED50 and ED90 are measures of:

Potency

10

The dose-response curve shifts ----- with:  increased  affinity for receptor + higher potency + lower dose required

Left

11

The dose-response curve shifts to the ----- with decreased affinity for receptor + lower potency + higher dose required

Right

12

Potency becomes clear when we compare two drugs. For example, let's compare drug A and drug B. Both are excellent analgesics that share a similar efficacy. This is because they reach the same ----- on the y-axis

height

13

Potency becomes clear when we compare two drugs. For example, let's compare drug A and drug B. Both are excellent analgesics that share a similar efficacy (they reach the same height on the y-axis). Which drug is more potent?

Drug A is more potent than drug B

14

Potency becomes clear when we compare two drugs. For example, let's compare drug A and drug B. Both are excellent analgesics that share a similar efficacy (they reach the same height on the y-axis). Drug A is more potent than drug B, and this explains why the curve for drug B is shifted to the -----.

Right

15

----- is a measure of the intrinsic ability of a drug to elicit a given clinical effect

Efficacy

16

The height of the plateau on the ----- axis represents Efficacy

Y-axis

17

The height of the plateau on the y-axis represents efficacy. A higher plateau implies a ----- efficacy

 

 

greater

18

The height of the plateau on the y-axis represents efficacy. A higher plateau implies a greater efficacy, while a lower plateau reflects a lower efficacy

True

19

In terms of drug efficacy, Once the plateau phase is reached, additional drug ----- additional effect

"does NOT produce"

20

In terms of drug efficacy, Once the plateau phase is reached, additional drug does NOT produce additional effect. Additional drug will increase the risk of

Toxicity

21

Efficacy becomes clear when comparing two drugs. For example, let's compare drug  A with drug B.  Although both drugs provide analgesia, drug ----- does a better job - it is more efficacious.

Drug A

22

Efficacy becomes clear when comparing two drugs. For example, let's compare drug  A with drug B.  Although both drugs provide analgesia, drug A does a better job - it is more efficacious. If we compared the dose-response curves of these drugs, we would see that drug A's plateau would be ----- on the y-axis than that of drug B

Higher

23

Efficacy becomes clear when comparing two drugs. For example, let's compare drug  A with drug B.  Although both drugs provide analgesia, drug A does a better job - it is more efficacious. If we compared the dose-response curves of these drugs, we would see that drug A's plateau would be higher on the y-axis than that of drug B. Also, the drug B curve is shifted to the right because it is ----- potent than drug A

Less potent

[See notebook for illustration]

24

The ----- tells us how many of the receptors must be occupied to elicit a clinical effect.

Slope

25

A ----- slope implies that most of the receptors must be occupied before we observe the clinical response

Steep slope

26

A steep slope implies that most of the receptors must be occupied before we observe the clinical response. Once the effect is observed, small increases in the dose can have a ----- clinical effect

"profound"

27

Which drugs have a steep slope?

Neuromuscular blockers and

Inhaled anesthetics

28

A particular dose may provide an excellent clinical effect in one patient, but offer no benefit in another. This is otherwise known as:

Individual Variability

29

Differences between ----- and ----- between patients explain individual variability

Pharmacokinetics and Pharmacodynamics

30

You need dose-response curves from ----- to get an accurate representation of individual variability

Multiple patients