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1

Pharmacodynamics is the study of:

Study on!!!!!

2

----- can be thought of as "what the body does to the drug."

Pharmacokinetics

3

Pharmacokinetics explains the relationship between the dose that you administer and the drug's ----- over time

Plasma concentration

4

Pharmacokinetics explains the relationship between the dose that you administer and the drug's plasma concentration over time. This relationship is affected by which four factors?

Absorption

Distribution

Metabolism

Elimination

5

The -----, otherwise known as the effect site, is the specific area of the body where the drug engages its receptor

Biophase

6

The drug concentration in the ----- determines its clinical effect

A. Biophase 

B. Plasma

Biophase

(not the plasma)

7

The drug concentration in the biophase (not the plasma) determines its clinical effect. Let's look at an example where we administer a cisatracurium bolus and continuously measure its serum concentration. After one minute, you'll notice that the plasma concentration is already -----.

"decreasing"

8

The drug concentration in the biophase (not the plasma) determines its clinical effect. Let's look at an example where we administer a cisatracurium bolus and continuously measure its serum concentration. After one minute, you'll notice that the plasma concentration is already decreasing, while the clinical effect (degree of muscle relaxation) continues to -----.

"rise"

9

The drug concentration in the biophase (not the plasma) determines its clinical effect. Let's look at an example where we administer a cisatracurium bolus and continuously measure its serum concentration. After one minute, you'll notice that the plasma concentration is already decreasing, while the clinical effect (degree of muscle relaxation) continues to rise. This is direct evidence that the plasma concentration ----- to clinical effect

 

"does not equate"

10

----- can be thought of as "what the drug does to the body."

Pharmacodynamics

11

Pharmacodynamics explains the relationship between the effect-site concentration and the -----.

Clinical effect

12

FYI

Pharmacokinetics Concepts You Must Understand include:

Volume of distribution

Half-lives

Metabolism

Enzyme induction and inhibition

Clearance

Steady-state

Context-sensitive half -time

Degree of ionization

Ion trapping

 


 

13

FYI

Pharmacobiophasics Concepts You Must Understand include:

Rate constants between the plasma and effect site

14

FYI

Pharmacodynamics Concepts You Must Understand include:

Potency - Efficacy

Dose-response curve slope

Agonist - Antagonist - Partial agonist

Inverse agonist

ED50 - LD50

Therapeutic index

Stereochemistry

15

16

Pharmacodynamics is the study of:

Effect site concentration and clinical effect

17

Which describes the relationship between drug dose and plasma concentration?

Pharmacokinetics

18

Which unites PK and PD by examining the relationship between plasma concentration and effect-site concentration?

Pharmaco-biophasics

19

Which describes the relationship between the effect-site concentration and the clinical effect

Pharmacodynamics

20

Reference:

 

Hemmings. Pharmacology and Physiology for Anesthesia: Foundations and Clinical Application. 1st ed. 2013. p. 23-25.