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SRNAClinical Practicuum Prep > DOSES only Induction agents > Flashcards

DOSES only Induction agents Flashcards

1
Q

Propofol IV induction dose is ______

A

1-2 mg/kg

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2
Q

Propofol IV maintenance dose is

A

20-200mcg/kg/min

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3
Q

Ketamine IV induction dose is

A

1 - 2mg/kg

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4
Q

Propofol antiemetic dose

A

10-20mg IV

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5
Q

Ketamine IV maintenance dose

A

1-3 mg/min

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6
Q

Ketamine analgesia dose

A

0.1-0.3 mg/kg

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7
Q

Ketamine IM dose is

A

4-8 mg/kg

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8
Q

Ketamine PO dose is

A

10mg/kg

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9
Q

Low dose OPIOD sparing effect of Ketamine

A

0.1 - 0.3mcg/kg/min

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10
Q

What is the intubation dose of Rocuronium?

A

0.6 - 1.2mg/kg

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11
Q

Atracurium intubation dosage

A

0.5 mg/kg

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12
Q

Cisatracurium intubation dosage

A

0.1 mg/kg

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13
Q

Neosynephrine (phenylepherine) infusion rate range?

A

0.15–0.75 µg⋅kg/min

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14
Q

Norepinephrine infusion rate

A

Start 0.01  µg⋅kg/min then titrate to effect

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15
Q

Vasopressin

A

0.01–0.04 units⋅min−1

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16
Q

Beta only dose EPI

A

0.01–0.03 µg⋅kg−1⋅min−1

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17
Q

Alpha and Beta EPI dose

A

0.03–0.1 µg⋅kg−1⋅min−1

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18
Q

Alpha and Beta EPI dose

A

0.03–0.1 µg⋅kg−1⋅min−1

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19
Q

More alpha Epi dose

A

> 0.1  µg⋅kg−1⋅min−1

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20
Q

Nitroprusside

A

0.5–10 µg/kg/min (bolus 1–2 µg/kg)

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21
Q

Nicardipine

A

5–15 mg/hr

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22
Q

Nitroglycerin

A

Initial infusion rate is typically 5 to 10 µg/min, and it is titrated in additional increments of 5 to 10 µg/min every 10 min to effect.

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23
Q

Diltiazem : intravenously as a bolus dose of

A

0.25 mg/kg, followed by a continuous infusion of 5 to 15 mg/min for the treatment of supraventricular tachycardia or atrial arrhythmias.

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24
Q

Dobutamine

A

2–20 µg⋅kg/min

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25
Milrinone
Loading dose of 20–50 µg⋅min–1, then 0.25–0.75 µg⋅kg–1⋅min–1
26
Isoproterenol
> 0.15 µg⋅kg/min
27
Ephedrine
5mg IVP for hypotension
28
Metoprolol
5mg IVP
29
Succinylcholine Low dose High dose
1-2 mg/kg | 3-4 mg/kg
30
Atropine dose for Bradycardia
0.5 mg Every 3-5 minutes | Max is 3 mg
31
Ondansetran
4mg IV , 8mg Max for cardiac
32
Naloxone (Narcan dose) How do you mix Duration is half life
``` 0.4mg in mL Aspirate the 1ml from vial add to 9ml of NS give you 40mcg/ml 30-45 mns 1 hour ```
33
Calcium Chloride
20mg/kg for CCB and Beta Blockers overdose | Cardiac arrest 1-2g
34
Vecuronium
0.8-1.2mg/kg
35
Esmolol
500mcg/kg loading dose over 1 min followed by 50 | mcg/kg/min infusion for 4 mins
36
Flumazenil
0.2 mg q 2min Max 1 mg
37
Glucagon
1mg q15 min
38
Calcium Chloride 2 uses and doses
20mg/kg for CCB and Beta Blockers overdose | Cardiac arrest 1-2g
39
Precedex
1mcg/kg
40
Sevo MAC
0.65
41
Des MAC
6.6
42
N2O
104
43
Albuterol class and use
Beta Adrenergic agonists, most potent bronchodilator, for asthma and COPD
44
Ipratropium
Anticholinergic , superior to SABA in patients with COPD
45
Dopamine (dosing scheme) onset Peak Duration
``` D B A Dopamine Dose 2-5 mcg/kg/min Beta Dose Dose 5-10 mcg/kg/min Alpha dose 10-20 mcg/kg/min Half life : 2 min O 5 min P D <10min ```
46
Ephedrine
synthetic non-catecholamine 5 mg Require 250X than epinephrine for the same response LAST LONGER
47
Epinephrine
1ml in 250 ml bag --> 4 mcg/ml | Drips is 1-16 mcg/kg/min
48
Glycopyrolate
0.01 - 0.02mg/kg IV | REVERSAL (0.2mg per 1 mg of Neostigmine)
49
Neostigmine
0. 04mg/kg for 2 TOF twitches | 0. 07 mg/kg for 4 TOF twitches
50
``` Nitroglycerine what about nipride? Concentration is Initial start dose How to titrate? ```
``` Venous dilator Nipride dilates both 25 mg in 250 ml bottle INITIAL DOSE IS 0.2 mcg/kg/min Titrate 0.1mcg /kg/min q3-5min ```
51
Nitroprusside Concentration Dose Toxicity
Arteriolar and veno vasodilator 50 mg in 250 ml 0.25- 5 mcg/kg/min Thiocynate Toxicity with > 3 mcg/kg/min
52
Norepinephrine Initial dose Bag concentration Alpha vs Beta
8mcg/min, titrate 2mcg/min q 5mins 4 mg in 250 ml = 16mcg/ml 8 mg in 250 ml = 32 mcg/ml ALPHA > BETA
53
Phenylephrine Most common infusion rate appears to be SPECIAL Because Effects on blood flow
40-80mcg/min Increases both arterial and venous blood vessels increasing SVR without changing cardiac dynamics. Decrease Blood flow to all organs Do not give with BRADYCARDIA cause it slows the HR
54
Alfentanil onset , peak , potency, duration, induction dose and intubation dose.
Onset is 1.4 minutes , 3-5 minutes Duration 30-60 minutes Less potent than remifentanyl, less apnea than remifentanyl Induction dose is 15 mcg/kg before direct laryngoscopy Intubation dose is 30mcg/kg to BLOCK the catecholamine response.
55
``` FENTANYL Equivalence to morphine Onset and duration Lipid solubility Half life Metabolism Excretion May cause this? ```
``` Most common use 100x more potent than morphine Rapid onset and short duration of action , 30-60mins Highly lipid soluble 2-4 hours Metabolism: Liver Excretion : Kidneys Chest wall rigidity ```
56
Hydromorphone Dose, onset, duration, potency when compared to morphine Receptors. Contraindications
``` Status asthmaticus, Increased ICP and intracranial lesions. Mu and Kappa 0.5 to 1 mg/hr IVP 2-5 min onset Duration 2-4 hours Half life is 2.3 hours ```
57
Labetalol Clinical dose Beta to alpha ratio is (oral or IV) Half time is _______
10-20 mg q10 mins 7: 1 IV 3: 1 oral
58
Metoprolol
k
59
Remifentanyl: Potency Onset, peak, duration,dose, solubility Always use as a
``` 19 x more potent than alfentan Rapid and Ultra short duration of action Onset 1.1 minutes Peak 2 minutes Less soluble than other 1-3 mcg/kg over 1 minute Continuous drip ```
60
Sodium Bicarbonate
Cardiac arrest 1 meq/kg/dose | For metabolic acidosis with ph<1
61
Induction dose of Esmolol | Induction dose is ____
Rapid onset, short duration of action 0.5mg/kg over 1 min Induction 100-150mg 2 min before laryngoscopy
62
When mixing phenylephrine: BAG mixing
``` Mix 10 mg vial in 250 ml of NS or D5W = 40 mcg/ml Mix 2 (10mg) vials in 250 ml of NS or D5W= 80mcg/ml ```
63
Half life for propofol infusion up to 8hrs
<40 minutes
64
Propofol is metabolized by | active metabolites?
Glucuronidation in the liver into inactive metabolites | no
65
Propofol time to peak
90-100 second (2mns)
66
Propofol onset
30 seconds
67
Propofol protein binding
98%
68
Vd of propofol
3-4L/kg
69
Propofol is made up of
Soybean oil glycerol egg
70
Propofol acid or base
Acid pka 11
71
Succinylcholine dose
0.5 - 1 mg/kg
72
Succinylcholine onset
30-60 sec
73
Succinylcholine Duration
3-5 minutes
74
Succinylcholine metabolism
Plasma cholinesterase
75
Side effects of succinylcholine
Bradycardia (most likely to be seen with a second dose)
76
How much do succ increase K
0.5 mEq
77
People who can metabolize succ
Atypical cholinesterase
78
Test done for people with atypical cholinesterase is
Dibucaine test
79
Normal dibucaine test is
80% (inhibit activity of plasma cholinesterase by 80%
80
Heterozygous dibucaine
40-60
81
homozygous dibucaine
20
82
Dibucaine number only refer to ____Not ____
Quality not quantity
83
What pressure do succinylcholine increases
IOP (ocular) IAP (abdominal) ICP (cranial)
84
Rocuronium onset
1-2 minutes
85
Rocuronium PEAK
60-90 seconds
86
Rocuronium duration
20-35 minutes
87
Rocuronium excretion
liver 70% | Renal 30%
88
Etomidate intubation dose
0.3-0.6mg/kg
89
Etomidate onset
30-60 seconds
90
Etomidate peak
1 minutes
91
Etomidate duration
3-10 minutes
92
Etomidate half time
2-5 hours
93
Etomidate Protein binding
76%
94
Limiting factor of etomidate
Adrenocortical function depression | PONV
95
ADvantage of etomidate
minimal changes with hemodynamics
96
How does etomidate causes adrenocortical suppresion?
Inhibits the enzyme 11-beta hydroxylase for 4-8 hours after induction. That enzyme converts cholesterol to cortisol, which patient needs to properly response to stress.
97
Ketamine causes at post op
Emergence delirium
98
Ketamine and airway
upper airway reflexes remain intact
99
Ketamine active metabolites
Yes , norketamine 1/3 as potent
100
Ketamine and bronchioles
Bronchodilation
101
Ketamine class
Binds noncompetitively to NMDA receptor
102
Ketamine onset
30 seconds
103
Ketamine peak
3-5 minutes
104
Ketamine duration
8-15 minutes
105
Vecuronium class
Monoquartery aminosteroid
106
Vecuronium intubation dose
0.08-0.1 mg/kg
107
Vecuronium onset
3-5 minutes
108
Vecuronium peak
3-5 minutes
109
Vecuronium duration
20-35 minutes
110
Vecuronium excretion
Liver 80% | Kidney 20%
111
Rocuronium class
Monoquartery aminosteroid
112
Cistracurium class
benzylisoquinolinium
113
CisAtracurium other name
Nimbex
114
Cisatracurium onset
1-5 minutes
115
Cisatracurium peak
3-5 minutes
116
Cisatracurium duration
25-35 minutes
117
Cisatracurium metabolims
Hoffman elimination
118
Cisatracurium metabolites
Laudnosine
119
Cistatracurium metabolizes to laudanosine which can cause
Seizures.
120
Duramorph is
derivatives free morphine
121
Duramorph intrathecal dose is
0.1-0.5 mg
122
Bupivacaine onset is
FAST
123
Max dose bupi without epi
175 mg (70 mls)
124
Max dose bupi with epi
225 ml (90mls)
125
Bupivacaine duration is
2-8 hours
126
Bupivacaine class
amide LA
127
What is the ED95 dose of Rocuronium?
0.3mg/kg
128
What is the ED95 dose of succinylcholine?
0.3mg/kg
129
What is the ED95 dose of Atracurium?
0.25mg/kg
130
What is the ED95 dose of Cisatracurium?
0.05mg/kg
131
What is the ED95 dose of Vecuronium?
0.05mg/kg

SRNAClinical Practicuum Prep (21 decks)

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