Dr. Atta Nutrition and Wound Healing Flashcards Preview

FHDM Unit 1: Wound Healing > Dr. Atta Nutrition and Wound Healing > Flashcards

Flashcards in Dr. Atta Nutrition and Wound Healing Deck (66)
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1

How many phases of wound healing are there? 

3 or 4 phase process depending on if you include hemostasis

2

What are the 3 phases of wound healing 

Inflammation  --*Hemostatis is included here

Proliferation 

Remodeling 

3

What is the goal of hemostasis

ensure the formation of the fibrin clot 

4

What are the 2 steps of hemostasis 

1. Vascular Constriction 

2. Platelet aggregation 

5

What happens in the inflammation stage 

1. neutrophil inflammation

2. monocyte infiltration and differentiation to macrophage

 

6

What are the 4 steps to the proliferation stage 

1. re-epithliazation

2. angiogeneis

3. collagen synthesis

4.ECM formation 

7

What happens during the remodeling stage

1. collagen remodeling 

2. Vascular maturation and regression

8

How does the inflammatory phase begin

formation of the fibrin clot 

9

What does hemostasis refer to 

the cessation of blood flow through a blood vessel or body tissue via a stable fibrin hemostatic plug

10

What are the important blood clotting factors

2,7,9,10

11

In order for thrombin to be converted to prothrombin what must occur 

protrombin (factor 2) must bind to calcium 

12

What do factor 2,7,9,10 all have in common 

they all have glutamic residues in the first 35 residues 

13

gamma glutamyl carboxylase is dependent on what 

vitamin K dependent 

14

What enzyme is needed to change glutamic acid to gamma glutamyl glutamic acid? What is also needed 

gamma glutamyl carboxylase. Needs factor K 

15

If a person has a vitamin k deficieny what will happen to blood clotting factors

you will have lower than normal levels of blood clotting factors 

16

what kind of drug is known as a vitamin k antagonist 

warfarin 

17

How does warfarin work? 

it inhibits the regeneration of vitamin K by inhibiting the reductase

18

How long does the inflammatory phase last 

4-6 days 

19

Which phase is this : associated with edema , erythema, heat, pain 

inflammatory 

20

list 3 cells involved in inflammatory phase 

platelets, neutrophiles, macrophages 

21

What phase is this:

1. clot formation

2. increased vessel permiability 

3. Neutrophil migration in tissue 

4. Macrophages release growth factors  

22

What the function of the growth factors that macrophages release in inflammation?

They release growth factors that stimulate fibroblast proliferation, and collagen synthesis 

23

What occurs during the first stage of the proliferation stage

granulation - connective tissue cells called fibroblasts proliferate under the growth factors that were secreted by macrophages (FGF-2)

24

What kind of collegen is found in the granulation phase 

type 3 

25

What does angiogeneiss refer to 

the sprouting of new blood vessels (stage 2 of phase 2)

26

What does contraction refer to?

What is the process mediated by?

What stage of wound healing is this? 

When the wound heals, the edges pull towards each other towards the center. This process is mediated by myofibroblasts. 

 

This happens during the proliferation phase

27

The process leading to the formation of the fibrin clot is called 

hemostasis 

28

What is an important vitamin needed in the hemostasis stage 

vitamin k- it activates factors 2,7,9,10

29

Describe the residues look like on factors 2,7.9,10

the have glutamate residues that must be gamma carboxylated so they can interact with calcium so that they can interact with phospholipids. 

30

what is needed to activate factors 2,7, 9 ,10 

vitamin K